Comparison of pathological characteristics between self-detected and screen-detected invasive breast cancers in Chinese women: a retrospective study.
Comparison of pathological characteristics between self-detected and screen-detected invasive breast cancers in Chinese women: a retrospective study.
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中国女性自我检测与筛查检测浸润性乳腺癌病理特征的比较：一项回顾性研究
作者：
Zhang Q;Ding L;Liang X;Wang Y;Jiao J;Lu W;Guo X
在中国，没有足够的证据支持筛查项目可以比患者自我报告更早发现乳腺癌并改善预后。因此，我们比较了在我们机构自我检测和筛查检测的浸润性乳腺癌病例之间诊断时的病理特征，并确定这些特征在项目引入后（与之前）是否不同。方法选择1995-2000年、2010年和2015年诊断的乳腺癌数据库，共提供3,014例女性浸润性乳腺癌患者。将病例分为自测组和筛查组。比较两组患者的病理学特征，采用多重填补和完全随机填补方法处理缺失数据。结果与患者自我报告相比，筛查与以下因素相关：T1期肿瘤比例较高（1995-2000年为75.0%比17.1%，P = 0.109; 2010年为66.7%比40.4%，P < 0.001; 2015年为67.8%比35.7%，P < 0.001）;具有N 0期淋巴结状态的肿瘤百分比较高（2010年为67.3%与48.4%，P = 0.007）;组织学I级肿瘤百分比较高（2010年为22.9%与13.9%，P = 0.017）。结论乳腺癌的筛查与更多的有利病理特征相关。然而，尽管筛查在中国的早期发现中具有有益的作用，但我们发现与西方和亚洲发达国家相比，本研究中通过筛查发现的患者较少。
Background In China, there is insufficient evidence to support that screening programs can detect breast cancer earlier and improve outcomes compared with patient self-reporting. Therefore, we compared the pathological characteristics at diagnosis between self-detected and screen-detected cases of invasive breast cancer at our institution and determined whether these characteristics were different after the program’s introduction (vs. prior to). Methods Three databases were selected (breast cancer diagnosed in 1995–2000, 2010, and 2015), which provided a total of 3,014 female patients with invasive breast cancer. The cases were divided into self-detected and screen-detected groups. The pathological characteristics were compared between the two groups and multiple imputation and complete randomized imputation were used to deal with missing data. Results Compared with patient self-reporting, screening was associated with the following factors: a higher percentage of stage T1 tumors (75.0% vs 17.1%, P = 0.109 in 1995–2000; 66.7% vs 40.4%, P < 0.001 in 2010; 67.8% vs 35.7%, P < 0.001 in 2015); a higher percentage of tumors with stage N0 lymph node status (67.3% vs. 48.4%, P = 0.007 in 2010); and a higher percentage of histologic grade I tumors (22.9% vs 13.9%, P = 0.017 in 2010). Conclusion Screen-detected breast cancer was associated with a greater number of favorable pathological characteristics. However, although screening had a beneficial role in early detection in China, we found fewer patients were detected by screening in this study compared with those in Western and Asian developed countries.
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影响因子：
3.9
作者：
Pedersen AB;Mikkelsen EM;Cronin-Fenton D;Kristensen NR;Pham TM;Pedersen L;Petersen I
通讯作者：
Petersen I
影响因子：
4
作者：
Eisemann N;Waldmann A;Katalinic A
通讯作者：
Katalinic A
影响因子：
6.4
作者：
Sankatsing, Valerie D. V.;van Ravesteyn, Nicolien T.;de Koning, Harry J.
通讯作者：
de Koning, Harry J.
影响因子：
3.8
作者：
Kim, Jiyoung;Lee, SeKyung;Yang, Jung-Hyun
通讯作者：
Yang, Jung-Hyun
影响因子：
6.2
作者：
Anderson, Benjamin O.;Yip, Cheng-Har;Harford, Joe
通讯作者：
Harford, Joe