Action of Thyroid Hormones, T3 and T2, on Hepatic Fatty Acids: Differences in Metabolic Effects and Molecular Mechanisms.
Action of Thyroid Hormones, T3 and T2, on Hepatic Fatty Acids: Differences in Metabolic Effects and Molecular Mechanisms.
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DOI：
10.3390/ijms18040744
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发表时间：
2017-03-31
影响因子：
5.6
通讯作者：
Siculella L
中科院分区：
文献类型：
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作者：
Damiano F;Rochira A;Gnoni A;Siculella L
甲状腺激素(TH)3，3‘，5，5’-四碘-L-甲状腺原氨酸(T4)和3，5，3‘-三碘-L-甲状腺原氨酸(T3)影响多种代谢途径。TH的主要生理功能是维持基础能量消耗，主要作用于碳水化合物和脂肪分解代谢。除了脂质的动员和降解外，在肝脏水平，TH还通过调节基因表达和快速激活细胞信号通路来刺激从头合成脂肪酸(DNL)。3，5-二碘-L-甲状腺原氨酸(T2)以前被认为只是一种T3分解代谢物，但已被证明模拟了T3对脂质分解代谢的一些影响。然而，T2的作用比T3更快，而且似乎不依赖于蛋白质的合成。已有文献证明T2对DNL有抑制作用。在此，我们就TH对肝脏脂肪酸代谢的作用机制进行综述，重点介绍T2和T3对DNL调节的不同作用。T2对DNL的抑制作用使该化合物成为治疗某些代谢性疾病和癌症的潜在和有吸引力的药物。
The thyroid hormones (THs) 3,3′,5,5′-tetraiodo-l-thyronine (T4) and 3,5,3′-triiodo-l-thyronine (T3) influence many metabolic pathways. The major physiological function of THs is to sustain basal energy expenditure, by acting primarily on carbohydrate and lipid catabolism. Beyond the mobilization and degradation of lipids, at the hepatic level THs stimulate the de novo fatty acid synthesis (de novo lipogenesis, DNL), through both the modulation of gene expression and the rapid activation of cell signalling pathways. 3,5-Diiodo-l-thyronine (T2), previously considered only a T3 catabolite, has been shown to mimic some of T3 effects on lipid catabolism. However, T2 action is more rapid than that of T3, and seems to be independent of protein synthesis. An inhibitory effect on DNL has been documented for T2. Here, we give an overview of the mechanisms of THs action on liver fatty acid metabolism, focusing on the different effects exerted by T2 and T3 on the regulation of the DNL. The inhibitory action on DNL exerted by T2 makes this compound a potential and attractive drug for the treatment of some metabolic diseases and cancer.