Towards a revised nomenclature for P1 and P2 receptors
Towards a revised nomenclature for P1 and P2 receptors
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DOI：
10.1016/s0165-6147(96)01038-3
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发表时间：
1997-03-01
影响因子：
13.8
通讯作者：
Williams, M
中科院分区：
文献类型：
--
作者：
Fredholm, BB;Abbracchio, MP;Williams, M
腺苷、ATP和ADP受体（统称为嘌呤受体）的分类在过去三年中取得了一些进展。Burnstock于1978年首次提出将受体分为两大类1（1）腺苷（P1）受体和（2）P2嘌呤受体（参考文献2），这一重要分类一直是一个持久的分类，为基于药理学特性将P2嘌呤受体进一步细分为P2 X和P2 Y亚型奠定了基础3。后来，Dubyak 4总结了ATP通过两种不同的转导机制起作用的证据：内在离子通道和G蛋白偶联受体。这一信息，加上1993/94年嘌呤受体的克隆，使Abbracchio和Burnstock 5提出嘌呤受体应分为两个家族：称为P2 Y嘌呤受体的G蛋白偶联受体和称为P2 X嘌呤受体的内在离子通道。近年来的发展证实了这些期望，现在可以提出一个修订的命名法，基本上采用了Abbracchio和Burnstock的建议。
The classification of receptors for adenosine, ATP and ADP (collectively called purinoceptors) has seen a number of developments in the past three years. The important division of receptors into two major classes1 (1) adenosine (P1) receptors and (2) P2 purinoceptors, first suggested by Burnstock in 1978 (Ref. 2), has been an abiding one that has set the stage for further subdivision of P2 purinoceptors into P2X and P2Y subtypes on the basis of pharmacological properties3. Later, Dubyak4 summarized the evidence that ATP worked through two different transduction mechanisms: intrinsic ion channels and G protein-coupled receptors. This information, coupled with the cloning of purinoceptors in 1993/94, led Abbracchio and Burnstock5 to propose that purinoceptors should be classified in two families: G protein-coupled receptors termed P2Y purinoceptors, and intrinsic ion channels termed P2X purinoceptors. Developments in recent years have borne out these expectations and a revised nomenclature, essentially adopting the Abbracchio and Burnstock proposal, can now be proposed.