Vesicle-mediated restoration of a plasmalemmal barrier in severed axons
Vesicle-mediated restoration of a plasmalemmal barrier in severed axons
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DOI：
10.1152/nips.01429.2002
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发表时间：
2003-06-01
期刊：
影响因子：
--
通讯作者：
Bittner, GD
中科院分区：
文献类型：
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作者：
Fishman, HM;Bittner, GD
在被切断的无脊椎动物巨型轴突中，钙离子诱导的内吞囊泡通过蛋白质介导的相互作用恢复选择性的通透性屏障和传播的动作电位。在培养的哺乳动物细胞中观察到类似的屏障修复现象，表明修复质膜损伤的细胞/分子机制在系统发育上是保守的。
Ca2+-induced endocytotic vesicles undergo protein-mediated interactions to restore a selectively permeable barrier and propagated action potentials in severed invertebrate giant axons. Similar barrier-restoration phenomena observed in cultured mammalian cells with transected neurites suggest that cellular/molecular mechanisms that repair plasmalemmal damage are phylogenetically conserved.