3D Bioprinting for Organ Regeneration.
3D Bioprinting for Organ Regeneration.
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DOI：
10.1002/adhm.201601118
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发表时间：
2017-01
影响因子：
10
通讯作者：
Zhang LG
中科院分区：
文献类型：
--
作者：
Cui H;Nowicki M;Fisher JP;Zhang LG
再生医学有望通过工程化功能组织或器官来治愈或替代异常和坏死的组织/器官，为填补器官短缺与移植需求之间的差距提供了希望。三维（3D）生物打印正在发展成为一种无与伦比的生物制造技术，因为它具有针对患者特定设计的高集成潜力，具有高分辨率的精确和快速制造能力以及前所未有的多功能性。它能够精确控制多种成分、空间分布和结构精度/复杂性，从而实现靶组织和器官的微结构、结构、机械性能和生物学功能的有效再现。在这里，我们概述了3D生物打印技术的最新进展，以及适用于生物打印过程的生物墨水的设计概念。我们专注于这项技术在活体器官工程中的应用，更具体地说，专注于血管系统、神经网络、心脏和肝脏。最后，我们总结了当前的挑战和3D器官生物打印进一步发展的技术前景。
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled bio-manufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs. Here we provide an overview of recent advances in 3D bioprinting technology, as well as design concepts of bioinks suitable for the bioprinting process. We focus on the applications of this technology for engineering living organs, focusing more specifically on vasculature, neural networks, the heart and liver. We conclude with current challenges and the technical perspective for further development of 3D organ bioprinting.