Association of body mass index and survival in pediatric leukemia: a meta-analysis
Association of body mass index and survival in pediatric leukemia: a meta-analysis
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DOI：
10.3945/ajcn.115.124586
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发表时间：
2016-03-01
影响因子：
7.1
通讯作者：
Ladas, Elena J.
中科院分区：
文献类型：
--
作者：
Orgel, Etan;Genkinger, Jeanine M.;Ladas, Elena J.
背景：肥胖是一种世界性的流行病，在儿童和青少年。成人队列研究已经报道了较高的体重指数（BMI）和白血病相关死亡率增加之间的关联;儿童白血病是否存在类似的影响仍然存在争议。目的：我们进行了一项荟萃分析，以确定儿童急性淋巴细胞白血病（ALL）或急性髓细胞白血病（AML）诊断时较高的BMI是否与无事件生存期（EFS）、总生存期（OS）、设计：我们检索了从开始到2015年3月的4个电子数据库，没有语言限制，并纳入了儿童ALL或AML（0-21岁）的研究，报告BMI作为生存或复发的预测因子。将较高的BMI定义为肥胖（>= 95%）或超重/肥胖（>= 85%），与较低的BMI [非超重/肥胖（
Background: Obesity is a worldwide epidemic in children and adolescents. Adult cohort studies have reported an association between higher body mass index (BMI) and increased leukemia related mortality; whether a similar effect exists in childhood leukemia remains controversial.Objective: We conducted a meta-analysis to determine whether a higher BMI at diagnosis of pediatric acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) is associated with worse event-free survival (EFS), overall survival (OS), and cumulative incidence of relapse (CIR).Design: We searched 4 electronic databases from inception through March 2015 without language restriction and included studies in pediatric ALL or AML (0-21 y of age) reporting BMI as a predictor of survival or relapse. Higher BMI, defined as obese (>= 95%) or overweight/obese (>= 85%), was compared with lower BMI [non-overweight/obese (