Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images.
Adaptation in cone photoreceptors contributes to an unexpected insensitivity of primate On parasol retinal ganglion cells to spatial structure in natural images.
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DOI：
10.7554/elife.70611
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发表时间：
2022-03-14
期刊：
影响因子：
7.7
通讯作者：
Rieke F
中科院分区：
文献类型：
--
作者：
Yu Z;Turner MH;Baudin J;Rieke F
神经电路是由非线性构建模块构成的，因此毫不奇怪，整个电路行为通常是强非线性的。但是神经回路也可以表现出近似线性的行为，有些回路会根据刺激条件从线性行为转变为非线性行为。这种对非线性电路行为的控制是神经计算的基础。在这里，我们研究了一个令人惊讶的刺激依赖性的响应猕猴上（但不是关闭）阳伞视网膜神经节细胞：这些细胞响应非线性的空间结构在一些刺激，但接近线性的空间结构在其他人，包括自然输入。我们表明，这些差异的线性整合的空间输入可以解释的兴奋性和抑制性突触输入的平衡，起源至少部分从适应锥光感受器的转变。更一般地说，这突出了信号传递中的微妙不对称性--这里是锥细胞信号--可以定性地改变电路计算。
Neural circuits are constructed from nonlinear building blocks, and not surprisingly overall circuit behavior is often strongly nonlinear. But neural circuits can also behave near linearly, and some circuits shift from linear to nonlinear behavior depending on stimulus conditions. Such control of nonlinear circuit behavior is fundamental to neural computation. Here, we study a surprising stimulus dependence of the responses of macaque On (but not Off) parasol retinal ganglion cells: these cells respond nonlinearly to spatial structure in some stimuli but near linearly to spatial structure in others, including natural inputs. We show that these differences in the linearity of the integration of spatial inputs can be explained by a shift in the balance of excitatory and inhibitory synaptic inputs that originates at least partially from adaptation in the cone photoreceptors. More generally, this highlights how subtle asymmetries in signaling – here in the cone signals – can qualitatively alter circuit computation.