Francisella tularensis Susceptibility toAntibiotics: A Comprehensive Review of the Data Obtained In vitro and in Animal Models
Francisella tularensis Susceptibility toAntibiotics: A Comprehensive Review of the Data Obtained In vitro and in Animal Models
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DOI：
10.3389/fcimb.2017.00122
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发表时间：
2017-04-11
影响因子：
5.7
通讯作者：
Maurin, Max
中科院分区：
文献类型：
--
作者：
Caspar, Yvan;Maurin, Max
推荐用于土拉菌病治疗的抗生素类别是氨基糖苷类、氟喹诺酮类和四环素类。然而，治愈率在60%到100%之间变化，这取决于所使用的抗生素，适当的抗生素治疗设置的时间和持续时间，以及是否存在并发症，如淋巴结化脓。因此，土拉菌菌株的抗生素药敏试验（AST）对于检测对一线药物的抗生素耐药性以及测试新的治疗方案仍然至关重要。然而，文献中报道的AST方法在研究之间的标准化程度很低，AST数据以前没有以全面和比较的方式进行评估。本综述的目的是总结自1989年引入氟喹诺酮类药物治疗土拉菌血症以来，在脱细胞培养基、细胞模型和动物模型中获得的土拉菌对抗生素敏感性的实验数据。我们收集了33种抗生素（包括氨基糖苷类、氟喹诺酮类、四环素类、大环内酯类、β -内酰胺类、氯霉素、利福平和利奈唑胺）对900株土拉菌（504株人类菌株）（包括107亚种）的MIC数据。土拉菌（A型），789亚种。全北极（B型）和四个亚种。用各种AST方法测定纵纵菌菌株。鉴定或确认了不适合土拉菌AST的特定培养基。总体而言，环丙沙星的mic最低(
The antibiotic classes that are recommended for tularaemia treatment are the aminoglycosides, the fluoroquinolones and the tetracyclines. However, cure rates vary between 60 and 100% depending on the antibiotic used, the time to appropriate antibiotic therapy setup and its duration, and the presence of complications, such as lymph node suppuration. Thus, antibiotic susceptibility testing (AST) of F. tularensis strains remains of primary importance for detection of the emergence of antibiotic resistances to first-line drugs, and to test new therapeutic alternatives. However, the AST methods reported in the literature were poorly standardized between studies and AST data have not been previously evaluated in a comprehensive and comparative way. The aim of the present review was to summarize experimental data on antibiotic susceptibilities of F. tularensis obtained in acellular media, cell models and animal models since the introduction of fluoroquinolones in the treatment of tularaemia in 1989. We compiled MIC data of 33 antibiotics (including aminoglycosides, fluoroquinolones, tetracyclines, macrolides, beta-lactams, chloramphenicol, rifampicin, and linezolid) against 900 F. tularensis strains (504 human strains), including 107 subsp. tularensis (type A), 789 subsp. holarctica (type B) and four subsp. mediasiatica strains, using various AST methods. Specific culture media were identified or confirmed as unsuitable for AST of F. tularensis. Overall, MICs were the lowest for ciprofloxacin (