RAPID RECOVERY FROM MASSIVE DIAZEPAM OVERDOSE
RAPID RECOVERY FROM MASSIVE DIAZEPAM OVERDOSE
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DOI：
10.1001/jama.240.17.1872
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发表时间：
1978-01-01
影响因子：
120.7
通讯作者：
SHADER, RI
中科院分区：
文献类型：
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作者：
GREENBLATT, DJ;WOO, E;SHADER, RI
两名患者在服用大剂量地西泮（500 和 2000 毫克）并有自杀意图后，因中度深度昏迷而入院。两名患者均未出现严重并发症；两人均已完全康复并在 48 小时内出院。在住院期间和住院后抽取的多个样本中测定了地西泮及其 3 种药理活性代谢物（去甲基地西泮、替马西泮和奥沙西泮）的浓度。早期样品中所有 4 种化合物的浓度都很高，然后在接下来的 1-2 周内缓慢下降。地西泮过量服用后临床快速恢复并非归因于活性化合物从体内的快速消除，而更可能归因于对其抑制作用的适应或耐受。
Two patients were hospitalized in moderately deep coma after ingestion of large doses of diazepam (500 and 2000 mg) with suicidal intent. Neither patient experienced important complications; both recovered fully and were discharged within 48 h. Concentrations of diazepam and its 3 pharmacologically active metabolites (desmethyldiazepam, temazepam and oxazepam) were determined in multiple samples drawn during and after hospitalization. High concentrations of all 4 compounds were present in early samples, then declined slowly during the next 1-2 wk. Rapid clinical recovery after diazepam overdose is not attributable to rapid elimination of active compounds from the body, but more likely to adaptation or tolerance to their depressant effects.