Positive Association Between Perfluoroalkyl Chemicals and Hyperuricemia in Children
Positive Association Between Perfluoroalkyl Chemicals and Hyperuricemia in Children
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DOI：
10.1093/aje/kws392
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发表时间：
2013-06-01
影响因子：
5
通讯作者：
Shankar, Anoop
中科院分区：
文献类型：
--
作者：
Geiger, Sarah Dee;Xiao, Jie;Shankar, Anoop
儿童的高尿酸血症与高血压、代谢综合征和未来心血管疾病的风险增加有关。血清全氟辛酸(PFOA)和全氟辛烷磺酸(PFOS)水平已被证明与成人的高尿酸血症呈正相关，但在儿童中的相关性仍未被探索。因此，我们在具有代表性的美国儿童样本中研究了血清全氟辛酸和全氟辛烷磺酸水平与高尿酸血症之间的关系。一项横断面研究对1,772名18岁的参与者进行，这些参与者来自19992000和20032008年度国家健康和营养检查调查。感兴趣的主要结果是高尿酸血症，定义为血清尿酸水平6 mg/dL。我们发现，血清全氟辛酸和全氟辛烷磺酸水平与高尿酸血症呈正相关，与年龄、性别、种族/民族、体重指数、家庭年收入、体力活动、血清总胆固醇和血清可替宁水平无关。与第一个分位数的受试者(参考)相比，第四个分位数的受试者高尿酸血症的多变量调整优势比为1.62(95可信区间：1.10，2.37)，全氟辛烷磺酸为1.65(95可信区间：1.10，2.49)。我们的发现表明，即使在美国普通人群背景暴露水平较低的情况下，血清全氟烷基化学水平也与儿童的高尿酸血症显著相关。
Hyperuricemia in children is associated with increased risk of high blood pressure, metabolic syndrome, and future cardiovascular disease. Serum perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) levels have been shown to be positively associated with hyperuricemia in adults, but the association in children remains unexplored. We therefore examined the association between serum PFOA and PFOS levels and hyperuricemia in a representative sample of US children. A cross-sectional study was performed on 1,772 participants 18 years of age from the National Health and Nutrition Examination Survey 19992000 and 20032008. The main outcome of interest was hyperuricemia, defined as serum uric acid levels 6 mg/dL. We found that serum levels of PFOA and PFOS were positively associated with hyperuricemia, independent of age, sex, race/ethnicity, body mass index, annual household income, physical activity, serum total cholesterol, and serum cotinine levels. Compared with subjects in quartile 1 (referent), subjects in quartile 4 had multivariable-adjusted odds ratios for hyperuricemia of 1.62 (95 confidence interval: 1.10, 2.37) for PFOA and 1.65 (95 confidence interval: 1.10, 2.49) for PFOS. Our findings indicate that serum perfluoroalkyl chemical levels are significantly associated with hyperuricemia in children even at the lower background exposure levels of the US general population.