Cancer cell behaviors mediated by dysregulated pH dynamics at a glance
Cancer cell behaviors mediated by dysregulated pH dynamics at a glance
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DOI：
10.1242/jcs.195297
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发表时间：
2017-02-15
影响因子：
4
通讯作者：
Barber, Diane L.
中科院分区：
文献类型：
--
作者：
White, Katharine A.;Grillo-Hill, Bree K.;Barber, Diane L.
与正常细胞相比，细胞内pH升高(pH(I))和细胞外pH(pH(E))降低是癌细胞的共同特征。最近的工作扩大了我们对失调的pH动态如何影响癌细胞行为的知识，包括增殖、转移、代谢适应和肿瘤发生。新出现的数据表明，癌症的pH失调通过改变被称为pH传感器的选择性pH敏感蛋白的结构和功能，使这些特定的细胞行为得以实现。最近的发现还表明，通过阻断phi的增加，癌细胞的行为可以减弱。这表明离子转运体抑制是一种有效的治疗方法，无论是单独使用还是与靶向治疗联合使用。在这篇《细胞科学概览》的文章和海报中，我们强调了失调的pH动态在癌症的发生、发展和适应中的相互关联的作用。
Dysregulated pH is a common characteristic of cancer cells, as they have an increased intracellular pH (pH(i)) and a decreased extracellular pH (pH(e)) compared with normal cells. Recent work has expanded our knowledge of how dysregulated pH dynamics influences cancer cell behaviors, including proliferation, metastasis, metabolic adaptation and tumorigenesis. Emerging data suggest that the dysregulated pH of cancers enables these specific cell behaviors by altering the structure and function of selective pH-sensitive proteins, termed pH sensors. Recent findings also show that, by blocking pHi increases, cancer cell behaviors can be attenuated. This suggests ion transporter inhibition as an effective therapeutic approach, either singly or in combination with targeted therapies. In this Cell Science at a Glance article and accompanying poster, we highlight the interconnected roles of dysregulated pH dynamics in cancer initiation, progression and adaptation.