Association between PADI4 and rheumatoid arthritis:: a meta-analysis
Association between PADI4 and rheumatoid arthritis:: a meta-analysis
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DOI：
10.1093/rheumatology/kel023
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发表时间：
2006-07-01
期刊：
影响因子：
5.5
通讯作者：
Kamatani, N.
中科院分区：
文献类型：
--
作者：
Iwamoto, T.;Ikari, K.;Kamatani, N.
目标。据报道，肽精氨酸脱亚胺酶4型基因（PADI4）的多态性和单倍型与日本人群中的类风湿性关节炎（RA）有关。然而，随后的重复研究显示了相互矛盾的结果。本研究的目的是确定荟萃分析是否能证明这种关联的存在。PubMed使用“PADI4”搜索从第一篇研究发表到2005年12月的文章。对验证PADI4与RA之间关联的重复性研究进行荟萃分析。计算了研究间的布雷斯罗-戴伊同质性检验。使用Mantel-Haenszel程序合并优势比（OR）和95%置信区间（CI）来评估相关性。6项重复性研究，1项来自日本，5项来自欧洲和北美，符合纳入meta分析的选择标准。在重复研究中证实了同质性。等位基因分布的共同OR为1.14 （95% CI = 1.07-1.21）。只有在欧洲血统人群中合并了5个重复研究（P = 0.0096，常见OR = 1.10），这种关联才得到证实。我们的荟萃分析显示，不仅在日本人群中，而且在欧洲血统人群中，PADI4与RA之间存在正相关。
Objective. Polymorphisms and haplotypes of the peptidylarginine deiminase type 4 gene (PADI4) have been reported to be associated with rheumatoid arthritis (RA) in a Japanese population. However, subsequent replication studies showed conflicting results. The aim of this study was to determine whether meta-analysis would prove the existence of the association.Methods. PubMed was searched using the term 'PADI4' for articles from the publication of the first study to December 2005. Replication studies that tested the association between PADI4 and RA were reviewed for meta-analysis. The Breslow-Day test for homogeneity across the studies was calculated. The Mantel-Haenszel procedure was used to pool odds ratios (OR) with 95% confidence intervals (CI) to evaluate the association.Results. Six replication studies, one from Japan and five from Europe and North America, fulfilled the selection criteria for inclusion in the meta-analysis. Homogeneity was confirmed across the replication studies. The common OR was 1.14 (95% CI = 1.07-1.21) for allelic distribution. The association was confirmed when only five replication studies in the European descent populations were combined (P = 0.0096, common OR = 1.10).Conclusions. Our meta-analysis showed a positive association between PADI4 and RA not only in the Japanese population but also in populations of European descent.