A protocol for amide bond formation with electron deficient amines and sterically hindered substrates
A protocol for amide bond formation with electron deficient amines and sterically hindered substrates
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DOI：
10.1039/c5ob02129d
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发表时间：
2016-01-14
影响因子：
3.2
通讯作者：
Ulven, Trond
中科院分区：
文献类型：
--
作者：
Due-Hansen, Maria E.;Pandey, Sunil K.;Ulven, Trond
已经开发了通过原位形成酰基氟并在升高的温度下与胺反应的酰胺偶联方案，并且发现其对于标准方法失败的空间位阻底物和缺电子胺的偶联是有效的。
A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.