Thirty-minute motor imagery exercise aided by EEG sensorimotor rhythm neurofeedback enhances morphing of sensorimotor cortices: a double-blind sham-controlled study
Thirty-minute motor imagery exercise aided by EEG sensorimotor rhythm neurofeedback enhances morphing of sensorimotor cortices: a double-blind sham-controlled study
复制标题
DOI：
10.1093/cercor/bhac525
复制
发表时间：
2023-01-03
期刊：
影响因子：
3.7
通讯作者：
Ushiba, Junichi
中科院分区：
文献类型：
--
作者：
Kodama, Midori;Iwama, Seitaro;Ushiba, Junichi
使用基于脑电图 (EEG) 的脑机接口 (BCI) 与运动行为的心理演练相结合的神经反馈训练已经证明了运动皮层兴奋性的成功自我调节。然而，目前尚不清楚自主控制神经兴奋性的技能的获得是否伴随着神经反馈增强的结构可塑性。在这里，我们寻求 30 分钟基于 BCI 的神经反馈训练引起的皮质结构的短期变化，其目的是调节头皮脑电图的感觉运动节律 (SMR)。当参与者通过对侧感觉运动皮层（SM1）或其他参与者（即安慰剂）的 SMR 幅度的事件相关去同步化（ERD）在线反馈进行右手手指运动的动觉运动想象时，SMR-ERD 控制的学习率显着不同。尽管两组中灰质体积的结构变化存在重叠，但逐组比较显示的显着差异在空间上存在差异；真正的神经反馈组表现出感觉运动区域特异性的变化，而安慰剂则表现出空间分布的变化。白质变化表明 Verum 组胼胝体显着减少。此外，SMR 调节的学习率与同侧 SM1 的体积变化相关，表明半球间运动控制电路参与了 BCI 控制任务。
Neurofeedback training using electroencephalogram (EEG)-based brain-computer interfaces (BCIs) combined with mental rehearsals of motor behavior has demonstrated successful self-regulation of motor cortical excitability. However, it remains unclear whether the acquisition of skills to voluntarily control neural excitability is accompanied by structural plasticity boosted by neurofeedback. Here, we sought short-term changes in cortical structures induced by 30 min of BCI-based neurofeedback training, which aimed at the regulation of sensorimotor rhythm (SMR) in scalp EEG. When participants performed kinesthetic motor imagery of right finger movement with online feedback of either event-related desynchronisation (ERD) of SMR magnitude from the contralateral sensorimotor cortex (SM1) or those from other participants (i.e. placebo), the learning rate of SMR-ERD control was significantly different. Although overlapped structural changes in gray matter volumes were found in both groups, significant differences revealed by group-by-group comparison were spatially different; whereas the veritable neurofeedback group exhibited sensorimotor area-specific changes, the placebo exhibited spatially distributed changes. The white matter change indicated a significant decrease in the corpus callosum in the verum group. Furthermore, the learning rate of SMR regulation was correlated with the volume changes in the ipsilateral SM1, suggesting the involvement of interhemispheric motor control circuitries in BCI control tasks.