Gender specificity of body adiposity and circulating adiponectin, visfatin, insulin, and insulin growth factor-I at term birth:: Relation to prenatal growth
Gender specificity of body adiposity and circulating adiponectin, visfatin, insulin, and insulin growth factor-I at term birth:: Relation to prenatal growth
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DOI：
10.1210/jc.2008-0526
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发表时间：
2008-07-01
影响因子：
5.8
通讯作者：
de Zegher, Francis
中科院分区：
文献类型：
--
作者：
Ibanez, Lourdes;Sebastiani, Giorgia;de Zegher, Francis
背景：根据足月出生时的血清内脂素和脂联素判断，胎儿发育被认为对肥胖、循环胰岛素和 IGF-I 具有性别特异性，但对脂肪细胞血症不具有性别特异性。我们研究了这些性别特异性与胎儿生长之间的潜在关系。地点：该研究在一所大学医院进行。研究人群：受试者包括 96 名严格匹配的出生时符合胎龄的新生儿（AGA；24 名女孩，24 名男孩）或小于胎龄的新生儿（SGA；24 名女孩，24 名男孩）。主要结果：结果包括血清胰岛素、IGF-I、内脂素、总和高分子量 (HMW) 脂联素、足月出生时的骨钙素以及吸收测定法测定的新生儿身体成分。结果：女孩的脐带胰岛素和 IGF-I 水平高于男孩（ P
Context: Fetal development is thought to be gender specific for adiposity and circulating insulin and IGF-I but not adipokinemia, as judged by serum visfatin and adiponectin at term birth. We studied the potential relationship between these gender specificities and fetal growth.Setting: The study was conducted at a university hospital.Study Population: Subjects included 96 strictly matched neonates born appropriate for gestational age (AGA; 24 girls, 24 boys) or small for gestational age (SGA; 24 girls, 24 boys).Main Outcomes: Outcomes included serum insulin, IGF-I, visfatin, total and high-molecular-weight (HMW) adiponectin, osteocalcin at term birth, and neonatal body composition by absorptiometry.Results: Cord insulin and IGF-I levels were higher in girls than boys ( P