The prognostic role of programmed cell death-ligand 1 expression in non-small cell lung cancer patients: An updated meta-analysis
The prognostic role of programmed cell death-ligand 1 expression in non-small cell lung cancer patients: An updated meta-analysis
复制标题
程序性细胞死亡配体 1 表达在非小细胞肺癌患者中的预后作用：更新的荟萃分析
DOI：
10.1016/j.cca.2018.03.038
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发表时间：
2018-07-01
影响因子：
5
通讯作者：
Zhou, Qinghua
中科院分区：
文献类型：
--
作者：
Ma, Guangzhi;Deng, Yunfu;Zhou, Qinghua
Background: Programmed cell death-ligand 1 (PD-L1) seemed to be associated with the outcomes of non-small cell lung cancer. However the prognostic role of PD-Ll expression among NSCLC remained unclear and inconsistent. The aim of the study set out to evaluate the correlation between PD-L1 expression and the prognosis of patients that developed NSCLC.Methods: Identified literatures were extracted of various electronic databases and a meta-analysis was performed to evaluate the prognostic role of PD-Ll among NSCLC patients.Results: Totally 25 studies from 11 countries containing 5861 patients were included in the meta-analysis. The pooled hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS) were 1.176 (95% CI: 1.016-1.361, P = 0.029) and 1.170 (95% CI: 0.984-1.392, P = 0.076), respectively. High PD-Ll expression on NSCLC tissue was also related with worse OS among Asian patients (HR = 1.381, 95% CI: 1.127-1.629, P = 0.002), adenocarcinomas (HR = 1.899, 95% CI: 1.306-2.762, P = 0.001) and poor PFS in non-Asian patients (HR = 1.695, 95% CI: 1.158-2.480, P = 0.002). Sensitivity analysis indicated that removal of any particular included literature won't affect the pooled results. Publication bias among the studies was not significant neither.Conclusions: PD-Ll expression is a prognostic factor related with poor survival among patients that developed NSCLC.
