Green tea, soy, and mammographic density in Singapore Chinese women.
Green tea, soy, and mammographic density in Singapore Chinese women.
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DOI：
10.1158/1055-9965.epi-08-0132
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Yu MC
中科院分区：
文献类型：
--
作者：
Wu AH;Ursin G;Koh WP;Wang R;Yuan JM;Khoo KS;Yu MC
来自观察性研究的越来越多的证据表明，乳腺癌风险与大豆和绿茶的摄入量成反比。我们通过对3315名在新加坡的中国女性的乳房X光检查和验证食物频率问卷的横断面分析，研究了这两种饮食制剂对乳房X光检查密度的影响，乳房X光检查密度是乳腺癌风险的一个公认的生物标志物。使用可重复性的计算机辅助方法评估百分比乳房摄影密度(PMD)。我们使用广义线性模型通过摄入大豆、绿茶和红茶来估计PMD，同时调整了潜在的混杂因素。在调整相关协变量后，每天喝绿茶的人PMD(19.5%)显著低于不喝茶的人(21.7%；P=0.002)。每天喝绿茶的人和不喝绿茶的人之间的PMD在调整大豆因素后仍然具有统计学意义(P=0.002)；这种影响在低大豆消费者(第一季度至第三季度；21.9%对19.4%；P=0.002)中比在高大豆消费者(20.9%对19.5%；P=0.32)中更明显。红茶摄入量与PMD无关。只有在报告大豆摄入量(Q4)非常高的绝经后妇女中，与大豆摄入量较少的妇女相比，PMD和大豆摄入量之间存在任何关联(18.9%对20.5%；P=0.035)。在调整绿茶摄入量后，大豆和PMD之间的相关性不再具有统计学意义(P=0.52)。我们的发现表明，常规绿茶和高大豆摄入量都可能对乳房有益；绿茶对PMD的影响可能比大豆更强。
There is increasing evidence from observational studies that breast cancer risk is inversely associated with soy and green tea consumption. We investigated the effects of these two dietary agents on mammographic density, a well-established biomarker for breast cancer risk, in a cross-sectional analysis of mammograms and validated food frequency questionnaires from 3,315 Chinese women in Singapore. Percent mammographic density (PMD) was assessed using a reproducible computer-assisted method. We used generalized linear models to estimate PMD by intake of soy, green tea, and black tea while adjusting for potential confounders. Daily green tea drinkers showed statistically significantly lower PMD (19.5%) than non-tea drinkers (21.7%; P = 0.002) after adjusting for relevant covariates. This difference in PMD between daily green tea drinkers and non-tea drinkers remained statistically significant after adjustment for soy (P = 0.002); the effect was more apparent among lower soy consumers (Q1–Q3; 21.9% versus 19.4%; P = 0.002) than in higher (Q4) consumers (20.9% versus 19.5%; P = 0.32). Black tea intake was unrelated to PMD. Only among postmenopausal women who reported very high soy intake (Q4) compared with those with less soy intake was there any association noted between PMD and soy intake (18.9% versus 20.5%; P = 0.035). Following adjustment for green tea intake, the association between soy and PMD was no longer statistically significant (P = 0.52). Our findings suggest that both regular green tea and high soy intake may have beneficial effects on the breast; the effect of green tea on PMD may be stronger than the effect of soy.