Nuclear factor kappa B
Nuclear factor kappa B
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DOI：
10.1016/s1357-2725(96)00159-8
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发表时间：
1997-06-01
影响因子：
4
通讯作者：
Barnes, PJ
中科院分区：
文献类型：
--
作者：
Barnes, PJ
核因子-κ B NF-κ B（NF-κ B）是一种普遍存在的转录因子，其通过调节多种炎症和免疫基因的表达，在宿主防御和慢性炎性疾病中起关键作用。它是异源二聚体，以与抑制性蛋白I κ B复合的无活性形式存在于细胞质中。许多细胞外刺激物，包括病毒、氧化剂、炎性细胞因子和免疫刺激物，激活NF-κ B。一旦被激活，它就与炎性和免疫基因的启动子区中的识别元件结合，如促炎细胞因子、趋化因子、炎性酶和粘附分子。糖皮质激素抑制活化的NF-κ B，这可能在类固醇的抗炎作用中是重要的。NF-κ B的新型抑制剂目前正在开发中，用于治疗炎性疾病，例如哮喘、类风湿性关节炎和炎性肠病。(C)1997年爱思唯尔科学有限公司
Nuclear factor-kappa B (NF-kappa B) is a ubiquitous transcription factor that, by regulating the expression of multiple inflammatory and immune genes, plays a critical role in host defence and in chronic inflammatory diseases, It is a heterodimer, present in the cytoplasm in an inactive form complexed to an inhibitory protein, I kappa B, Many extracellular stimuli, including viruses, oxidants, inflammatory cytokines and immune stimuli, activate NF-kappa B, Once activated, it binds to recognition elements in the promoter regions of inflammatory and immune genes, such as proinflammatory cytokines, chemokines, inflammatory enzymes and adhesion molecules. Glucocorticoids inhibit activated NF-kappa B and this is likely to be important in the anti-inflammatory action of steroids, Novel inhibitors of NF-kappa B are now under development for treatment of inflammatory diseases such as asthma, rheumatoid arthritis and inflammatory bowel disease. (C) 1997 Elsevier Science Ltd.