Systematic review of wastewater surveillance of antimicrobial resistance in human populations
Systematic review of wastewater surveillance of antimicrobial resistance in human populations
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DOI：
10.20944/preprints202010.0267.v2
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发表时间：
2021-06
影响因子：
11.8
通讯作者：
K. Chau;L. Barker;E. Budgell;K. Vihta;N. Sims;B. Kasprzyk-Hordern;E. Harriss;D. Crook;D. Read;S. Walker;N. Stoesser
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文献类型：
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作者：
K. Chau;L. Barker;E. Budgell;K. Vihta;N. Sims;B. Kasprzyk-Hordern;E. Harriss;D. Crook;D. Read;S. Walker;N. Stoesser
亮点·尽管方法多样，但废水-人类AMR关联的检测仍很有前景。·包括复合进水，12个月的时间框架和WwTW-人类重叠似乎是最佳的。·特定物种和AMR机制似乎比其他物种更适合该方法。·基因组方法有助于不可知检测和生物统计合成。·需要更多的研究和明确的报告，以验证“最佳做法”的协议。
Highlights • Detection of wastewater-human AMR associations is promising despite diverse methods.• Including composite influent, 12-month timeframe and WwTW-human overlap appears optimal.• Specific species and AMR mechanisms appear more suited to the approach than others.• Genomic approaches facilitate agnostic detection and biostatistical synthesis.• More studies with clear reporting are needed to validate “best practice” protocols.