SEQUENTIAL GENE ACTION IN ESTABLISHMENT OF LYSOGENY
SEQUENTIAL GENE ACTION IN ESTABLISHMENT OF LYSOGENY
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DOI：
10.1126/science.146.3651.1581
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发表时间：
1964-01-01
期刊：
影响因子：
56.9
通讯作者：
SMITH, HO
中科院分区：
文献类型：
--
作者：
LEVINE, M;SMITH, HO
对噬菌体 P22 温度敏感的透明噬菌斑形成突变体的研究表明，C1 和 C2 基因座在鼠伤寒沙门氏菌溶原性的建立中必须按时间顺序发挥作用。 C1位点在感染的第7分钟和第11分钟之间仅作用4分钟的间隔。 C2 基因座在几分钟后开始发挥作用，其持续活动对于溶原状态的永久化是必要的。
A study of temperature sensitive clear-plaque-forming mutants of bacteriophage P22 demonstrates that the C1 and C2 loci must function in a temporal sequence in the establishment of lysogeny in Salmonella typhimurium. The C1 locus acts for only a 4-minute interval between the 7th and 11th minute of the infection. The C2 locus begins to function some minutes later, and its continued activity is necessary for perpetuation of the lysogenic state.