LOW VITAMIN-E CONTENT IN PLASMA OF PATIENTS WITH ALCOHOLIC LIVER-DISEASE, HEMOCHROMATOSIS AND WILSONS-DISEASE
LOW VITAMIN-E CONTENT IN PLASMA OF PATIENTS WITH ALCOHOLIC LIVER-DISEASE, HEMOCHROMATOSIS AND WILSONS-DISEASE
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DOI：
10.1016/s0168-8278(05)80465-9
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发表时间：
1994-01-01
影响因子：
25.7
通讯作者：
SIES, H
中科院分区：
文献类型：
--
作者：
VONHERBAY, A;DEGROOT, H;SIES, H
The RRR-alpha-tocopherol (vitamin E) content in plasma from 46 patients with liver diseases and 23 healthy controls was determined by high performance liquid chromatography and electrochemical detection. Patients were divided into three groups: alcoholic liver diseases (n=17; group A), hemochromatosis (n=17; group B) and Wilson's disease (n=12; group C). Lipid-standardized alpha-tocopherol levels were determined to neutralize differences due to hyperlipemia. The ratio of serum vitamin E to serum lipids (cholesterol, triglycerides, phospholipids) was highest in healthy controls and in patients in group A with cirrhosis and normal transaminases and bilirubin. Patients in group A with acute or chronic ethanol intoxication and high bilirubin levels had a 37% lower lipid-standardized vitamin E level than controls. Patients in group B with hemochromatosis, showing high serum iron (>180 mu g/dl), a low free iron binding capacity (
