Palladium-Catalyzed Denitrogenation Reaction of 1,2,3-Benzotriazin-4(3H)-ones Incorporating Isocyanides
Palladium-Catalyzed Denitrogenation Reaction of 1,2,3-Benzotriazin-4(3H)-ones Incorporating Isocyanides
复制标题
DOI：
10.1021/ol103143a
复制
发表时间：
2011-03-18
期刊：
影响因子：
5.2
通讯作者：
Murakami, Masahiro
中科院分区：
文献类型：
--
作者：
Miura, Tomoya;Nishida, Yui;Murakami, Masahiro
1,2,3-苯并三嗪-4(3H)- 1和1,2,3,4-苯并噻唑三嗪- 1,1(2H)- 2在钯催化剂的存在下与异氰酸酯反应，分别得到3-（亚氨基）异吲哚-1- 1和3-（亚氨基）噻唑三嗪- 1,1-二氧化物，产率高。通过三嗪部分脱氮生成中间氮杂氮杂环，并在其中掺入异氰化物。
1,2,3-Benzotriazin-4(3H)-ones and 1,2,3,4-benzothiatriazine 1,1(2H)-dioxide reacted with isocyanides in the presence of a palladium catalyst to give 3-(imino)isoindolin-1-ones and 3-(Imino)thiaisoindoline 1,1-dioxides, respectively, In high yield. An intermediate azapalladacycie was generated through denitrogenation of the triazine moiety, and an isocyanide was Incorporated therein.