Epicardium-Derived Heart Repair.
Epicardium-Derived Heart Repair.
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DOI：
10.3390/jdb2020084
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发表时间：
2014-04-10
影响因子：
2.7
通讯作者：
Riley PR
中科院分区：
文献类型：
--
作者：
Smits AM;Riley PR
在过去的十年中，细胞替代疗法已成为治疗心肌梗死（MI）患者的潜在方法。移植或局部刺激具有形成新心脏组织能力的祖细胞为克服MI后心肌大量丧失提供了一种新的策略。在这方面，心外膜，心脏的外层，是一个易于处理的局部祖细胞群的治疗追求。心外膜在胚胎心脏的形成中起着至关重要的作用。在激活和迁移到发育中的心肌后，心外膜细胞分化成几种心脏细胞类型。此外，心外膜还为心肌生长和冠状动脉血管生成提供指导信号。在成人心脏中，心外膜是静止的，但最近的证据表明，它在受损后会重新激活，并重演至少部分胚胎功能。在这篇综述中，我们提供了一个更新的知识，心外膜细胞的贡献，成年哺乳动物心脏在损伤反应。
In the last decade, cell replacement therapy has emerged as a potential approach to treat patients suffering from myocardial infarction (MI). The transplantation or local stimulation of progenitor cells with the ability to form new cardiac tissue provides a novel strategy to overcome the massive loss of myocardium after MI. In this regard the epicardium, the outer layer of the heart, is a tractable local progenitor cell population for therapeutic pursuit. The epicardium has a crucial role in formation of the embryonic heart. After activation and migration into the developing myocardium, epicardial cells differentiate into several cardiac cells types. Additionally, the epicardium provides instructive signals for the growth of the myocardium and coronary angiogenesis. In the adult heart, the epicardium is quiescent, but recent evidence suggests that it becomes reactivated upon damage and recapitulates at least part of its embryonic functions. In this review we provide an update on the current knowledge regarding the contribution of epicardial cells to the adult mammalian heart during the injury response.