Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand
Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand
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DOI：
10.1039/c5mt00077g
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发表时间：
2015-01-01
期刊：
影响因子：
3.4
通讯作者：
Hureau, C.
中科院分区：
文献类型：
--
作者：
Atrian-Blasco, E.;Cerrada, E.;Hureau, C.
尽管铜离子的这种氧化还原状态具有生物学相关性，但在阿尔茨海默病背景下的铜（I）配位配体仍然未被探索。在这里，我们表明PTA配体可以从抗体中去除铜，防止活性氧的产生和低聚物的形成，这是疾病病因学中的两个有害事件。
Copper(I) coordinating ligands in the Alzheimer's disease context have remained unexplored, despite the biological relevance of this redox state of the copper ion. Here, we show that the PTA ligand can remove copper from Ab, prevent reactive oxygen species production and oligomer formation, two deleterious events in the disease's etiology.