Research Needs for Prognostic Modeling and Trajectory Analysis in Patients with Disorders of Consciousness.
Research Needs for Prognostic Modeling and Trajectory Analysis in Patients with Disorders of Consciousness.
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DOI：
10.1007/s12028-021-01289-y
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发表时间：
2021-07
影响因子：
3.5
通讯作者：
Curing Coma Campaign and its Contributing Members
中科院分区：
文献类型：
--
作者：
Hammond FM;Katta-Charles S;Russell MB;Zafonte RD;Claassen J;Wagner AK;Puybasset L;Egawa S;Laureys S;Diringer M;Stevens RD;Curing Coma Campaign and its Contributing Members
关于意识障碍患者的护理和预后的科学现状是有限的。需要科学进步来提高准确性、相关性和说明方法，从而为制定有意义和有效的干预措施奠定基础。为了满足这一需求，一个跨学科的专家小组被创建为神经重症监护学会治愈昏迷运动的昏迷科学工作组的一部分。专家组进行了差距分析，确定了预测建模和轨迹分析的七项研究需求（“恢复科学”）：（1）定义预测结果的变量;（2）定义不同内型在特定时间点的有意义的中间结果;（3）描述在没有护理限制的情况下的恢复轨迹;（4）利用大数据并开发分析方法以更准确地进行预测;（5）确定随着时间的推移传达预后不确定性的关键要素和过程;（6）确定促进恢复和恢复科学的医疗保健提供模式;以及（7）倡导医疗保健提供系统的变革，以推进康复科学并实施已知的最佳实践。本报告总结了目前的研究，以告知拟议的研究需求，阐明了每个领域内的关键要素，并讨论了成功解决这些需求所预期的恢复科学和护理的目标和进展。
The current state of the science regarding the care and prognosis of patients with disorders of consciousness is limited. Scientific advances are needed to improve the accuracy, relevance, and approach to prognostication, thereby providing the foundation to develop meaningful and effective interventions. To address this need, an interdisciplinary expert panel was created as part of the Coma Science Working Group of the Neurocritical Care Society Curing Coma Campaign. The panel performed a gap analysis which identified seven research needs for prognostic modeling and trajectory analysis (“recovery science”) in patients with disorders of consciousness: (1) to define the variables that predict outcomes; (2) to define meaningful intermediate outcomes at specific time points for different endotypes; (3) to describe recovery trajectories in the absence of limitations to care; (4) to harness big data and develop analytic methods to prognosticate more accurately; (5) to identify key elements and processes for communicating prognostic uncertainty over time; (6) to identify health care delivery models that facilitate recovery and recovery science; and (7) to advocate for changes in the health care delivery system needed to advance recovery science and implement already-known best practices. This report summarizes the current research available to inform the proposed research needs, articulates key elements within each area, and discusses the goals and advances in recovery science and care anticipated by successfully addressing these needs.
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DOI：
10.1038/s41582-020-00428-x
发表时间：
2021-03
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Edlow BL;Claassen J;Schiff ND;Greer DM
通讯作者：
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影响因子：
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作者：
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DOI：
10.1016/j.apmr.2012.12.028
发表时间：
2013-10-01
影响因子：
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作者：
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通讯作者：
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影响因子：
2.4
作者：
Giacino, JT;Kalmar, K
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影响因子：
9.9
作者：
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