Protracted increases in core body temperature and interleukin-1 following acute administration of lipopolysaccharide: Implications for the stress response
Protracted increases in core body temperature and interleukin-1 following acute administration of lipopolysaccharide: Implications for the stress response
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DOI：
10.1016/j.physbeh.2005.04.016
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发表时间：
2005-06-30
影响因子：
2.9
通讯作者：
Bordner, KA
中科院分区：
文献类型：
--
作者：
Deak, T;Bellamy, C;Bordner, KA
注射脂多糖(LPS)会引起发热反应，通常是由中枢神经系统中促炎症细胞因子的产生引起的。这种促炎症的级联反应传统上被认为是一种短暂的事件，在非复制抗原(如脂多糖)的作用下，会在几个小时内消退。我们提供的数据显示，在某些结构中，在内毒素后48小时，中枢和外周IL-1水平显著升高。为了探索疾病反应的其他方面可能遵循类似的延长时间过程，在大鼠体内植入遥测探头并注射(Ip)。注射0、10或100 mg/kg的内毒素，静置96h后，大鼠出现多相发热，中温高峰在5和8h左右。虽然发烧似乎在第一个夜间周期中消退，但更详细的分析证实，它被黑暗周期中核心温度的昼夜上升所掩盖，实际上在脂多糖之后持续了大约36天。相反，内毒素产生了一种短暂的社会互动抑制，这种抑制在内毒素后24小时不再明显。最后，我们报告了先前的内毒素在48小时后对社会冲突产生了致敏的发热反应。综上所述，这些结果表明，急性给予内毒素会导致持续发热反应和IL-1升高，并持续至少24-48小时，并且内毒素可能使应激反应的某些方面变为致敏状态。(C)2005 Elsevier Inc.保留所有权利。
Administration of lipopolysaccharide (LPS) produces a fever response often precipitated by the production of pro-inflammatory cytokines in the CNS. This pro-inflammatory cascade has traditionally been regarded as a transitory event that, with a non-replicating antigen such as LPS, would subside within a few hours. We present data showing that central and peripheral levels of IL-1 were substantially elevated as much as 48 h after LPS in some structures. In order to explore other aspects of the sickness response that might follow a similarly protracted time course, rats were implanted with telemetry probes and injected (i.p.) with 0, 10 or 100 mu g/kg of LPS and left undisturbed for 96 h. Rats injected with LPS evinced a polyphasic fever with intermediate temperature peaks at approximately 5 and 8 It. Although the fever appeared to subside during the first night cycle, more detailed analysis confirmed that it was masked by the circadian rise in core temperature during the dark cycle and actually persisted for approximately 36 It following LPS. In contrast, LPS produced a transient suppression of social interaction that was no longer evident 24 It after LPS. Finally, we report that prior LPS produced a sensitized fever response to social conflict 48 h later. Taken together, these results suggest that acute administration of LPS results in a protracted fever response and increased IL-1 that persist for at least 24-48 h, and that LPS may render certain aspects of the stress response to a sensitized state. (c) 2005 Elsevier Inc. All rights reserved.