Expression and hypoxic up-regulation of neuroglobin in human glioblastoma cells
Expression and hypoxic up-regulation of neuroglobin in human glioblastoma cells
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DOI：
10.1016/j.molonc.2008.11.002
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发表时间：
2009-02-01
影响因子：
6.6
通讯作者：
Allalunis-Turner, Joan
中科院分区：
文献类型：
--
作者：
Emara, Marwan;Salloum, Nicole;Allalunis-Turner, Joan
脑红蛋白是最近发现的一种主要在脊椎动物脑中表达的珠蛋白分子。脑红蛋白表达在缺氧神经元中增加，表明它保护神经元免于缺血性细胞死亡。我们报告，脑红蛋白的转录本和蛋白质在人胶质母细胞瘤细胞中表达，并且这种表达在体外缺氧中增加。我们还表明，神经红蛋白上调，在缺氧微区的胶质母细胞瘤肿瘤异种移植。我们在人类胶质母细胞瘤细胞中发现的脑红蛋白的缺氧上调可能为了解肿瘤细胞如何适应缺氧微环境并在缺氧微环境中生存提供了线索。(C)2008年欧洲生物化学学会联合会。Elsevier B.V.出版，保留所有权利。
Neuroglobin is a recently identified globin molecule that is expressed predominantly in the vertebrate brain. Neuroglobin expression increases in oxygen-deprived neurons, suggesting it protects neurons from ischemic cell death. We report that neuroglobin transcript and protein are expressed in human glioblastoma cells, and that this expression increases in hypoxia in vitro. We also show that neuroglobin is up-regulated in hypoxic microregions of glioblastoma tumor xenografts. Our finding of hypoxic up-regulation of neuroglobin in human glioblastoma cells may provide insight into how tumor cells adapt to and survive in hypoxic microenvironments. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.