Efficacy of Exercise Interventions in Modulating Cancer-Related Fatigue among Adult Cancer Survivors: A Meta-Analysis
Efficacy of Exercise Interventions in Modulating Cancer-Related Fatigue among Adult Cancer Survivors: A Meta-Analysis
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DOI：
10.1158/1055-9965.epi-10-0988
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发表时间：
2011-01-01
影响因子：
3.8
通讯作者：
Johnson, Blair T.
中科院分区：
文献类型：
--
作者：
Brown, Justin C.;Huedo-Medina, Tania B.;Johnson, Blair T.
背景资料：这项荟萃分析的目的是探讨运动作为一种非药物干预措施在减少成年癌症幸存者癌症相关性疲劳（CRF）方面的疗效。我们还调查了运动处方（Ex R-x）的不同组成部分、方法学考虑因素和受试者特征如何调节CRF.Methods：使用与癌症、运动和疲劳相关的词对随机对照试验进行系统检索。总共有44项研究，48项干预措施合格，包括3，254名不同癌症类型，诊断阶段，治疗和运动干预的参与者。运动干预的癌症幸存者降低CRF水平的程度大于常规护理对照组，d（+）= 0.31（95% CI = 0.22-0.40），这种效应似乎在几种类型的癌症中普遍存在。CRF水平的改善与抗阻运动强度成正比（β = 0.60，P = 0.01），这种模式在高质量研究中更强（β = 0.23，P < 0.05）。当干预措施在理论上得到推动时，（β = 0.48，P < 0.001）或癌症幸存者年龄较大（beta = 0.24，P = 0.04）.结论：运动减少CRF，特别是在老年癌症幸存者中涉及中等强度抗阻运动和理论指导的项目中。影响：我们的研究结果表明，成年癌症幸存者的运动干预应该是多维度的，根据健康结果和癌症类型进行个性化。癌症流行病学生物标志物Prev; 20（1）; 123-33。(C)2011年AACR。
Background: The purpose of this meta-analysis was to explore the efficacy of exercise as a nonpharmacologic intervention to reduce cancer-related fatigue (CRF) among adult cancer survivors. We also investigated how different components of the exercise prescription (Ex R-x), methodologic considerations, and subject characteristics modulate CRF.Methods: A systematic search for randomized controlled trials was conducted using words related to cancer, exercise, and fatigue.Results: In total, 44 studies with 48 interventions qualified, including 3,254 participants of varying cancer types, stages of diagnosis, treatments, and exercise interventions. Cancer survivors in exercise interventions reduced their CRF levels to a greater extent than usual care controls, d(+) = 0.31 (95% CI = 0.22-0.40), an effect that appeared to generalize across several types of cancer. CRF levels improved in direct proportion to the intensity of resistance exercise (beta = 0.60, P = 0.01), a pattern that was stronger in higher quality studies (beta = 0.23, P < 0.05). CRF levels also reduced to a greater extent when interventions were theoretically driven (beta = 0.48, P < 0.001) or cancer survivors were older (beta = 0.24, P = 0.04).Conclusions: Exercise reduced CRF especially in programs that involved moderate-intensity, resistance exercise among older cancer survivors and that were guided by theory.Impact: Our results indicate exercise interventions for adult cancer survivors should be multi-dimensional and individualized according to health outcome and cancer type. Cancer Epidemiol Biomarkers Prev; 20(1); 123-33. (C) 2011 AACR.