Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women.
Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women.
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DOI：
10.1097/ypg.0b013e32833a220b
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发表时间：
2010-08
影响因子：
0.9
通讯作者：
Avramopoulos D
中科院分区：
文献类型：
--
作者：
Liu Y;Chen PL;McGrath J;Wolyniec P;Fallin D;Nestadt G;Liang KY;Pulver A;Valle D;Avramopoulos D
A single nucleotide polymorphism (rs7341475) in RELN has recently been shown to be associated with schizophrenia (SZ) in an Ashkenazi Jewish (AJ) case-control study specifically in women by Shifmen et al. We have replicated this association in women in another large independent AJ collection (721 cases, 259 female; 1455 controls, 834 female) and confirmed that it applies to both SZ and schizoaffective disorder. Further, we explore the effects of this polymorphism through quantitative trait loci (QTL) analysis of 9 SZ related factors providing information on sex-specific genotype-phenotype correlations.
