Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population
Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population
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DOI：
10.1164/ajrccm.156.5.9702084
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发表时间：
1997-11-01
影响因子：
24.7
通讯作者：
Hamaguchi, H
中科院分区：
文献类型：
--
作者：
Noguchi, E;Shibasaki, M;Hamaguchi, H
众所周知，哮喘和其他特应性疾病的易感性与遗传成分有关，据报道，几种候选基因与高加索人群的特应性有关。我们对68个日本家庭（306个成员）进行了哮喘与5q31-q33和11q13染色体标记之间的联系研究。通过访问过敏诊所的哮喘儿童确定参与关联研究的家庭。结果为哮喘与5q31-q33染色体上白细胞介素-4 （IL-4）基因、IL-9基因和D5S393基因或附近的基因标记之间的联系提供了支持性证据（p = 0.0013、p = 0.018和p = 0.0077）。特应性表型与这些遗传标记之间也存在联系（分别为p = 0.006, p = 0.01和p < 0.0001）。然而，我们未能找到哮喘或特应性与11q13上的IgE高亲和力受体基因相关的证据（p < 0.01）。这些发现表明，除了种族之外，染色体5q31-q33上还有一些特定的位点对特应性易感性有贡献。此外，我们的研究结果表明，染色体5q31-q33上的位点与儿童哮喘的发展有关。
Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components, and several candidate genes have been reported to be linked to atopy in Caucasian populations. We conducted a study of linkage between asthma and markers on chromosomes 5q31-q33 and 11q13 in 68 Japanese families (306 members) by affected sib-pair analysis. Families for the linkage study were ascertained through asthmatic children visiting the allergy clinic. The results provide supportive evidence for linkage between asthma and gene markers in or near the interleukin-4 (IL-4) gene, the IL-9 gene, and D5S393 on chromosome 5q31-q33 (p = 0.0013, p = 0.018, and p = 0.0077, respectively). Linkage between atopic phenotype and these genetic markers was also suggested (p = 0.006, p = 0.01, and p < 0.0001 for atopy, respectively). However, we failed to find evidence for linkage of asthma or atopy to the IgE high-affinity receptor gene on 11q13 (p > 0.1). These findings indicate that beyond ethnicity, there are specific loci that contribute to susceptibility to atopy on chromosome 5q31-q33. In addition, our findings suggest that loci on chromosome 5q31-q33 are linked to the development of asthma in childhood.