Striatal neurons encoded temporal information in duration discrimination task
Striatal neurons encoded temporal information in duration discrimination task
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DOI：
10.1007/s00221-008-1347-3
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发表时间：
2008-04-01
影响因子：
2
通讯作者：
Inase, Masahiko
中科院分区：
文献类型：
--
作者：
Chiba, Atsushi;Oshio, Ken-ichi;Inase, Masahiko
为了阐明基底神经节在时间知觉中的作用，记录了一只执行时长辨别任务的猴子两侧纹状体的单位活动。在任务中，两个视觉线索在不同的持续时间内被连续呈现(0.2个类似于1.6个S)。每次提示之后都会有一段1-S的延迟期。在第二个延迟期之后，受试者被指示选择一个更长的提示。关于线索持续时间序列的实验有两种类型，一种是第一条线索(C1)长于第二条线索(C2)的长-短(LS)实验，另一种是短-长(SL)实验，其第一条线索(C1)比第二条线索(C2)短。纹状体神经元在第一延迟(D1)和第二延迟(D2)时相性反应。D1期间的反应随c1持续时间的不同而变化。D_1反应神经元的活动与C_1时程呈正相关或负相关。LS试验和SL试验在D2期间的反应不同。D2反应神经元群的活动也随C2持续时间的不同而变化。但对C2时程的依赖性受到试验类型的影响，即C2比C1长还是短。这些结果表明，纹状体神经元可以编码线索时长，在D1期具有单调变化的反应，在D2期有两种线索时长的区分结果。
To clarify the roles of the basal ganglia in time perception, single-unit activity was recorded from both sides of the striatum of a monkey performing a duration discrimination task. In the task, two visual cues were presented successively in different durations (0.2 similar to 1.6 s). Each cue presentation was followed by a 1-s delay period. The subject was instructed to choose a longer presented cue after the second delay period. There were two types of trials for sequence of cue duration, the long-short (LS) trials in which the first cue (C1) was longer than the second cue (C2) and the short-long (SL) trials in which the C1 was shorter than the C2. Striatal neurons phasically responded during the first delay (D1) and second delay (D2) periods. Responses during the D1 period changed depending on C1 duration. Activity of populations of D1-response neurons correlated with C1 duration positively or negatively. Responses during the D2 period differed between the LS and SL trials. Activity of population of D2-response neurons also changed depending on C2 duration. But the dependence on C2 duration was affected by the trial type, that is, whether the C2 was longer or shorter compared to the C1.These findings suggest that striatal neurons could encode cue durations with monotonically changing responses in the D1 period and discrimination results between the two cue durations in the D2 period.