Inhibition of mammalian microsomal protein synthesis by aminoglycoside antibiotics.
Inhibition of mammalian microsomal protein synthesis by aminoglycoside antibiotics.
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氨基糖苷类抗生素抑制哺乳动物微粒体蛋白质合成。
DOI：
10.1093/jac/14.3.231
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Kauten,R
中科院分区：
文献类型：
--
作者：
Buss,WC;Piatt,MK;Kauten,R
氨基糖苷类抗生素庆大霉素、卡那霉素和奈替米星对从人肝和大鼠脑、肾和肝中分离的微粒体中的氨基酸掺入产生剂量依赖性抑制。对微粒体蛋白合成的抑制作用发生在治疗性给药后在啮齿动物和人肾皮质和外淋巴中蓄积的浓度下。在那些专门积累氨基糖苷类抗生素的组织中抑制翻译可能部分解释了暴露于氨基糖苷类抗生素后观察到的毒性。
The aminoglycoside antibiotics gentamicin, kanamycin and netilmicin produce a dose-dependent inhibition of amino acid incorporation in microsomes isolated from human liver and rat brain, kidney and liver. Inhibitory effects on microsomal protein synthesis occur at concentrations that have been shown to accumulate in rodent and human renal cortex and perilymph following therapeutic administration. Inhibition of translation in those tissues which specifically accumulate aminoglycoside antibiotics may, in part, explain toxicities observed following exposure to aminoglycosides.