Expanded Normal Weight Obesity and Insulin Resistance in US Adults of the National Health and Nutrition Examination Survey
Expanded Normal Weight Obesity and Insulin Resistance in US Adults of the National Health and Nutrition Examination Survey
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DOI：
10.1155/2017/9502643
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发表时间：
2017-01-01
影响因子：
4.3
通讯作者：
LeCheminant, James D.
中科院分区：
文献类型：
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作者：
Martinez, Keilah E.;Tucker, Larry A.;LeCheminant, James D.
本研究旨在使用 NHANES (1999-2006) 美国成年人样本来扩大对正常体重肥胖 (NWO) 及其与胰岛素抵抗的关系的评估。进行了一项包括 5983 名男性和女性 (50.8%) 的横断面研究。使用双能 X 射线吸收测定法评估体脂百分比 (BF%)。扩展的正常体重肥胖 (eNWO) 类别、BMI 和体脂百分比分类的配对是使用 BMI 的标准切点和 BF% 的性别特定中位数创建的。稳态模型评估-胰岛素抵抗（HOMA-IR）水平用于指数胰岛素抵抗。平均 +/- SE 值为 BMI：27.9 +/- 0.2（女性）和 27.8 +/- 0.1（男性）；体脂百分比：40.5 +/- 0.2（女性）和 27.8 +/- 0.2（男性）； HOMA-IR：2.04 +/- 0.05（女性）和 2.47 +/- 0.09（男性）。 HOMA-IR 在 eNWO 类别的所有级别中以剂量反应方式系统地存在差异（F = 291 3，P < 0 0001）。随着 BMI 水平的增加，HOMA-IR 显着增加，并且在每个 BMI 类别中，较高的体脂水平与较高的 HOMA-IR 水平相关。高 BMI 和高 BF% 均与胰岛素抵抗密切相关。胰岛素抵抗似乎主要根据体重指数水平逐渐增加，其次是根据身体脂肪水平。将体脂精确测量与 BMI 结合起来，对 BMI 在预测胰岛素抵抗方面的效用几乎没有什么帮助。
This study aims to expand the evaluation of normal weight obesity (NWO) and its association with insulin resistance using an NHANES (1999-2006) sample of US adults. A cross-sectional study including 5983 men and women (50.8%) was conducted. Body fat percentage (BF%) was assessed using dual-energy X-ray absorptiometry. Expanded normal weight obesity (eNWO) categories, pairings of BMI and body fat percentage classifications, were created using standard cut-points for BMI and sex-specific median for BF%. Homeostatic model assessment-insulin resistance (HOMA-IR) levels were used to index insulin resistance. Mean +/- SE values were BMI: 27.9 +/- 0.2 (women) and 27.8 +/- 0.1 (men); body fat percentage: 40.5 +/- 0.2 (women) and 27.8 +/- 0.2 (men); and HOMA-IR: 2.04 +/- 0.05 (women) and 2.47 +/- 0.09 (men). HOMA-IR differed systematically and in a dose-response fashion across all levels of the eNWO categories (F = 291 3, P < 0 0001). As BMI levels increased, HOMA-IR increased significantly, and within each BMI category, higher levels of body fat were associated with higher levels of HOMA-IR. Both high BMI and high BF% were strongly related to insulin resistance. Insulin resistance appears to increase incrementally according to BMI levels primarily and body fat levels secondarily. Including a precise measure of body fat with BMI adds little to the utility of BMI in the prediction of insulin resistance.