Mechanism of auditory hypersensitivity in human autism using autism model rats
Mechanism of auditory hypersensitivity in human autism using autism model rats
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DOI：
10.1111/ped.13186
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发表时间：
2017-04-01
影响因子：
1.4
通讯作者：
Narita, Masaaki
中科院分区：
文献类型：
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作者：
Ida-Eto, Michiru;Hara, Nao;Narita, Masaaki
背景听觉过敏是自闭症谱系障碍的主要并发症之一。本研究旨在探讨自闭症模型大鼠的听觉脑中枢是否受到影响。方法采用孕鼠胚胎第9天和第10天产前暴露沙利度胺制备自闭症模型大鼠。上橄榄复合体（SOC）是听觉核的复合体，在出生后第50天用抗钙结合蛋白d28k抗体进行免疫染色。结果在自闭症模型大鼠中，SOC免疫反应性显着降低。自闭症模型大鼠 SOC 听觉纤维的免疫染色强度也较弱。令人惊讶的是，在自闭症模型大鼠中，梯形体内侧核（SOC中发挥抑制功能的核）的大小显着减小。结论听觉超敏反应可能部分是由于听觉脑中枢的抑制处理受损所致。
BackgroundAuditory hypersensitivity is one of the major complications in autism spectrum disorder. The aim of this study was to investigate whether the auditory brain center is affected in autism model rats.MethodsAutism model rats were prepared by prenatal exposure to thalidomide on embryonic day 9 and 10 in pregnant rats. The superior olivary complex (SOC), a complex of auditory nuclei, was immunostained with anti-calbindin d28k antibody at postnatal day 50.ResultsIn autism model rats, SOC immunoreactivity was markedly decreased. Strength of immunostaining of SOC auditory fibers was also weak in autism model rats. Surprisingly, the size of the medial nucleus of trapezoid body, a nucleus exerting inhibitory function in SOC, was significantly decreased in autism model rats.ConclusionsAuditory hypersensitivity may be, in part, due to impairment of inhibitory processing by the auditory brain center.