Measles immunity and measles vaccine acceptance among healthcare workers in Paris, France
Measles immunity and measles vaccine acceptance among healthcare workers in Paris, France
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DOI：
10.1016/j.jhin.2013.01.002
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发表时间：
2013-05-01
影响因子：
6.9
通讯作者：
Loulergue, P.
中科院分区：
文献类型：
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作者：
Freund, R.;Krivine, A.;Loulergue, P.
背景：在欧洲，包括法国，麻疹疫情自2008年以来一直在持续。未受保护的医护人员（HCWs）可能会合同和传播infection to patients.Aim：本研究的目的是评估HCWs的麻疹免疫力和疫苗接受在我们setting.Methods：在一项基于调查的研究中进行的巴黎的三所大学医院，351 HCWs被纳入2011年4月至6月。在入组时收集以下数据：年龄、住院单位、职业、麻疹感染和疫苗接种史、既往麻疹血清学检查和在血清阴性情况下接受麻疹疫苗接种。使用CAPTIA（R）麻疹酶联免疫吸附试验检测血清中特异性抗麻疹IgG抗体的存在。结果：参与HCW的平均年龄为36岁（范围：18-67），278（79.2%）为女性。总共有104人（29.6%）宣称有麻疹病史，90人（25.6%）宣称从未接受过麻疹疫苗接种。在纳入研究的351名医务人员中，322名（91.7%）接受了麻疹免疫（IgG >90 mIU/mL）。未受保护的风险因素是年龄[18-29岁，校正比值比：2.7（95%置信区间：1.1-6.9）与>= 30岁相比]，无麻疹感染或疫苗接种史。结论：在本队列中，8.3%的医务人员对麻疹易感，年龄较大的人群对麻疹的易感性最高
Background: In Europe, including France, a measles outbreak has been ongoing since 2008. Unprotected healthcare workers (HCWs) may contract and spread the infection to patients.Aim: The objective of this study was to evaluate HCWs' measles immunity and vaccine acceptance in our setting.Methods: In a survey-based study conducted in three university hospitals in Paris, 351 HCWs were included between April and June 2011. The following data were collected at enrolment: age, hospital unit, occupation, history of measles infection and vaccination, previous measles serology and acceptance of a measles vaccination in case of seronegativity. Sera were tested for the presence of specific anti-measles IgG antibodies using the CAPTIA (R) measles enzyme-linked immunosorbent assay.Findings: The mean age of the participating HCWs was 36 years (range: 18-67) and 278 (79.2%) were female. In all, 104 four persons (29.6%) declared a history of measles, and 90 (25.6%) declared never having received a measles vaccination. Among the 351 HCWs included in the study, 322 (91.7%) were immunized against measles (IgG >90 mIU/mL). The risk factors for not being protected were age [18-29 years, adjusted odds ratio: 2.7 (95% confidence interval: 1.1-6.9) compared with >= 30 years], no history of measles infection or vaccination. The global acceptance rate for a measles vaccination, before knowing their results, was 78.6%.Conclusion: In this cohort of HCWs, 8.3% were susceptible to measles; the group most represented were aged