Sensitive determination of urapidil at an electrochemically pretreated glassy carbon electrode by linear sweep voltammetry
Sensitive determination of urapidil at an electrochemically pretreated glassy carbon electrode by linear sweep voltammetry
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DOI：
10.1039/c4ay01009d
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发表时间：
2014-08-21
影响因子：
3.1
通讯作者：
Ye, Baoxian
中科院分区：
文献类型：
--
作者：
Li, Kunjing;Li, Yinfeng;Ye, Baoxian
采用电化学预处理技术，以玻碳电极为伏安传感器，建立了一种测定乌拉地尔的伏安法。EPGCE通过在0.1M pH 7.0 PBS中使电极在-1.5至2.5V的电位之间循环五个循环来获得。与裸GCE相比，EPGCE对乌拉地尔的氧化反应具有良好的响应。在最佳条件下，乌拉地尔的线性范围为2.0 × 10（-8）~ 5.0 × 10（-6）mol L-1，检出限为2.0 × 10（-8）mol L-1。同时将该方法应用于乌拉地尔缓释片和尿样中乌拉地尔的含量测定，结果令人满意。
A very simple and sensitive voltammetric method for the determination of urapidil was proposed by electrochemical pretreatment using a glassy carbon electrode as the voltammetric sensor (EPGCE). The EPGCE was obtained by cycling the electrode between a potential of -1.5 and 2.5 V. for five cycles in 0.1 M pH 7.0 PBS. Compared with the bare GCE, the EPGCE had an excellent response towards the oxidation of urapidil. Under the optimal conditions, the selective detection of urapidil in a linear concentration range of 2.0 x 10(-8) to 5.0 x 10(-6) mol L-1 was obtained with a determination limit of 2.0 x 10(-8) mol L-1. At the same time, the EPGCE was also applied to the detection of urapidil content in urapidit sustained-release tablets and urine samples with satisfactory results.