Intramuscular fat and glucose tolerance after spinal cord injury - a cross-sectional study
Intramuscular fat and glucose tolerance after spinal cord injury - a cross-sectional study
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DOI：
10.1038/sj.sc.3101652
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发表时间：
2004-12-01
期刊：
影响因子：
2.2
通讯作者：
Dudley, GA
中科院分区：
文献类型：
--
作者：
Elder, CP;Apple, DF;Dudley, GA
研究设计：调查。目的：用一种新的分析方法测定完全性脊髓损伤后受损骨骼肌中的肌内脂肪(IMF)，并确定IMF与口服葡萄糖耐量试验中血糖或胰岛素的相关性。地点：美国佐治亚州雅典社区。方法：12名未接受运动训练的完全性脊髓损伤(SCI)患者(10名男性和2名女性，年龄40+/-12岁，平均年龄26-71岁，伤后8+/-5年)和9名非运动训练的非残疾(ND)对照组，年龄29+/-9岁，年龄23-51岁。在身高、体重和BMI匹配的情况下，对他们的大腿进行T-1磁共振成像，并在征得同意后进行口服葡萄糖耐量试验(OGTT)。结果：脊髓组和ND组的平均骨骼肌横截面积(CSA)分别为58.6±21.6 cm(2)和94.1+/-32.5 cm(2)。脊髓组平均IMF CSA为14.5+/-6.0 cm(2)，非残疾组为4.7+/-2.5 cm(2)，两者相差近4倍，分别为17.3+/-4.4%和4.6+/-2.6%。脊髓损伤组60、90、120min血糖或血胰岛素水平明显高于对照组。IMF(绝对值和%)与90或120min血糖或血浆胰岛素相关(r(2)=0.71~0.40)。结论：IMF是OGTT中血糖的良好预测因子，可能是糖耐量减低和2型糖尿病，尤其是脊髓损伤的发病因素之一。此外，有关骨骼肌CSA的报告应为国际货币基金组织更正。
Study design: Survey.Objective: Determine intramuscular fat (IMF) in affected skeletal muscle after complete spinal cord injury using a novel analysis method and determine the correlation of IMF to plasma glucose or plasma insulin during an oral glucose tolerance test.Setting: General community of Athens, GA, USA.Methods: A total of 12 nonexercise-trained complete spinal cord injured (SCI) persons (10 males and two females 40+/-12 years old (mean+/-SD), range 26-71 years, and 8+/-5 years post SCI) and nine nonexercise-trained nondisabled (ND) controls 29+/-9 years old, range 23-51 years, matched for height, weight, and BMI, had T-1 magnetic resonance images of their thighs taken and underwent an oral glucose tolerance test (OGTT) after giving consent.Results: Average skeletal muscle cross-sectional area (CSA) (mean+/-SD) was 58.6+/-21.6 cm(2) in spinal cord subjects and 94.1+/-32.5 cm(2) in ND subjects. Average IMF CSA was 14.5+/-6.0 cm(2) in spinal cord subjects and 4.7+/-2.5 cm(2) in nondisabled subjects, resulting in an almost four-fold difference in IMF percentage of 17.3+/-4.4% in spinal cord subjects and 4.6+/-2.6% in nondisabled subjects. The 60, 90 and 120 min plasma glucose or plasma insulin were higher in the SCI group. IMF (absolute and %) was related to the 90 or 120 min plasma glucose or plasma insulin (r(2) = 0.71-0.40).Conclusions: IMF is a good predictor of plasma glucose during an OGTT and may be a contributing factor to the onset of impaired glucose tolerance and type II diabetes, especially in SCI. In addition, reports of skeletal muscle CSA should be corrected for IMF.