Preferential loss of body fat during starvation in dietary obese rats.
Preferential loss of body fat during starvation in dietary obese rats.
复制标题
饮食肥胖大鼠饥饿期间体脂肪优先减少。
DOI：
10.1016/0024-3205(91)90292-j
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发表时间：
1991
期刊：
影响因子：
6.1
通讯作者：
DiGirolamo,M
中科院分区：
文献类型：
--
作者：
Hill,JO;DiGirolamo,M
这项研究的目的是研究饮食引起的肥胖是否会改变饥饿期间体重减轻的数量和/或组成。在给予大鼠（350 g体重）高脂饮食（HFD）之前、17周、30周和42周，测定4天饥饿期间体重损失的数量和组成。为了控制衰老的影响，第二组大鼠，喂食标准实验室食物，也经历了类似的饥饿时期。尽管在饥饿期间，HFD大鼠的总体重损失从来没有比食物喂养的大鼠大，但前者的身体脂肪和总能量的损失明显增加，并且在以后的生活中，随着饥饿的持续，无脂肪组织的保存也在增加。此外，在每段饥饿期间，低食大鼠都表现出大量的能量节约（即它们每天损失的能量比饥饿前的能量需求少）。相比之下，HFD大鼠仅在17周时表现出明显的能量节约，而在30或42周时则没有；在饥饿的最后阶段，它们的平均日胴体能量损失超过了饥饿前的能量需要量。这表明，这些大鼠的脂肪量增加可能导致了饥饿期间燃料供应的增加和代谢率的提高。如果这些结果适用于人类，那么越肥胖的受试者可能比瘦的受试者表现出更大的总能量损失，但瘦体重的损失较小，至少在最初是这样。如果蛋白质需求反映在限制食物时调动蛋白质的能力上，那么饮食肥胖大鼠的蛋白质需求将大大低于对照组。总之，饮食引起的肥胖导致在饥饿期间身体脂肪的优先损失和瘦质量的保存。
This study was undertaken to examine whether diet-induced obesity alters the amount and/or composition of weight lost during starvation. The amount and composition of weight lost during a 4-day period of starvation was determined before and at 17, 30 and 42 weeks after rats (350 g of body weight) were given a high fat diet (HFD). To control for effects of aging, a second group of rats, fed standard laboratory chow, was also subjected to similar periods of starvation. Although total weight loss during starvation was never greater for HFD rats than for chow-fed rats, the former group showed a clear patter of increasing loss of body fat and total energy and conservation of fat-free tissues with periods of starvation later in life. In addition, chow-fed rats showed substantial energy conservation during each period of starvation (i.e. they lost less energy each day than their pre-starvation energy requirements). In contrast, HFD rats demonstrated substantial energy conservation only at 17 weeks and not at 30 or 42 weeks; during the last period of starvation, their average daily loss of carcass energy exceeded their pre-starvation energy requirements. This suggests the increased fat mass of these rats may have led to increased fuel availability and to an increased metabolic rate during starvation. If these results are applicable to humans, the more obese subjects are likely to show greater total loss of energy than lean subjects, but show a lesser loss of lean body mass, at least initially. If protein requirements are reflected by the ability to mobilize protein during food restriction, protein requirements would be substantially lower in the dietary obese rats than in controls. In summary, diet-induced obesity leads to preferential loss of body fat and conservation of lean mass during starvation.