Asymmetric Total Synthesis of Propindilactone G
Asymmetric Total Synthesis of Propindilactone G
复制标题
丙二内酯G的不对称全合成
DOI：
10.1021/jacs.5b06480
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发表时间：
2015-08-19
影响因子：
15
通讯作者：
Yang, Zhen
中科院分区：
文献类型：
--
作者：
You, Lin;Liang, Xin-Ting;Yang, Zhen
首次合成了从五味子茎中分离得到的北三萜(+)-丙烯内酯G。合成的关键步骤包括一个不对称Diels-Alder反应、一个Pauson-Khand反应、一个pd催化的还原性氢解反应和一个氧化异偶联反应。这些反应使得合成(+)-丙迪内酯G只需20步。由于我们的合成研究，(+)-丙迪内酯G的结构已被修改。
A concise total synthesis of (+)-propindilactone G, a nortriterpenoid isolated from the stems of Schisandra propingua var. propingua, has been achieved for the first time. The key steps of the synthesis include an asymmetric Diels-Alder reaction, a Pauson-Khand reaction, a Pd-catalyzed reductive hydrogenolysis reaction, and an oxidative heterocoupling reaction. These reactions enabled the synthesis of (+)-propindilactone G in only 20 steps. As a consequence of our synthetic studies, the structure of (+)-propindilactone G has been revised.