INCREASED ESTROGEN PRODUCTION IN OBESE MEN
INCREASED ESTROGEN PRODUCTION IN OBESE MEN
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DOI：
10.1210/jcem-48-4-633
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发表时间：
1979-01-01
影响因子：
5.8
通讯作者：
ERTEL, NH
中科院分区：
文献类型：
--
作者：
SCHNEIDER, G;KIRSCHNER, MA;ERTEL, NH
血清雌酮（E1）和17 β-雌二醇（E2）在一组病态肥胖男性中升高2倍。尿E1和E2产生率与肥胖程度成比例地升高，值分别高达127和157 μ g/天。虽然肥胖男性的血清睾酮（T）浓度降低，平均为348 ± 100 mg/kg。35对519 .+-. 42 ng/dl，透析T分数升高，因此，计算的游离T浓度在肥胖男性中正常。肥胖男性对克罗米芬的血清LH、FSH和T反应正常，表明下丘脑-垂体-间质细胞轴完整。T的MCR [代谢清除率]和T向E2和雄烯二酮（Δ）的外周转化在肥胖男性中，E1与理想体重以上的百分比成比例增加。尽管肥胖男性表现出雌激素的血液水平和生产率增加，但没有女性化的迹象，T-雌激素结合球蛋白水平增加，或抑制基础促性腺激素水平，表明缺乏生物学效应。肥胖男性可能表现出雌激素受体缺陷，导致T-雌激素结合球蛋白减少，雄激素清除增加和雌激素产生率升高。
Serum estrone (E1) and 17.beta.-estradiol (E2) were noted to be 2-fold elevated in a group of morbidly obese men. Urinary E1 and E2 production rates were elevated in proportion to the degree of obesity, with values as high as 127 and 157 .mu.g/day, respectively. Although serum testosterone (T) concentrations were reduced in obese men, averaging 348 .+-. 35 vs. 519 .+-. 42 ng/dl in lean controls, the dialyzable T fractions were elevated and, hence, the calculated free T concentrations were normal in obese men. The obese men exhibited normal serum LH [lutropin], FSH [follitropin] and T responses to clomiphene citrate, indicating intact hypothalamic-pituitary-Leydig cell axes. MCR [metabolic clearance rate] of T and peripheral conversion of T to E2 and androstenedione (.DELTA.) to E1 were all increased in obese men in proportion to the percentage above ideal weight. Although the obese men exhibited increased blood levels and production rates of estrogens, there were no signs of feminization, increased T-estrogen-binding globulin levels, or suppressed basal gonadotropin levels, suggesting a lack of biological effect. Obese men may exhibit defective estrogen receptors, leadint to decreased T-estrogen-binding globulin, increased clearance of androgenic hormones and elevated estrogen production rates.