Current prevalence of HTLV-1 in Japan as determined by screening of blood donors
Current prevalence of HTLV-1 in Japan as determined by screening of blood donors
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DOI：
10.1002/jmv.23181
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发表时间：
2012-02-01
影响因子：
12.7
通讯作者：
Tadokoro, Kenji
中科院分区：
文献类型：
--
作者：
Satake, Masahiro;Yamaguchi, Kazunari;Tadokoro, Kenji
人类t细胞白血病病毒1型（HTLV-1）是成人t细胞白血病及相关疾病的主要来源，在日本西南部流行。通过母乳母婴传播是一种重要的感染途径，建立预防这种传播的方案需要HTLV-1患病率和携带者数量的确切数据。因此，我们调查了2006 - 2007年日本1196321名首次献血者HTLV-1的血清阳性率。共有3787名献血者被证实抗htlv -1抗体阳性。通过将适应度曲线应用于献血者年龄范围以外的年龄范围，估计目前日本0 - 99岁年龄段的HTLV-1携带者人数至少为108万；这一数值比1988年的报告低10%。调整后的男性和女性总体患病率估计分别为0.66%和1.02%。携带者数量的高峰出现在70多岁的人群中，这与1988年数据库中50多岁人群中观察到的上一个高峰有所不同。携带者不仅分布在日本西南流行地区，而且分布在全国各地，特别是在大东京大都市区。通过应用人口预测，计算出携带者数量将在未来20年内减少一半；然而，携带人群会在这段时间内变老，这意味着成人t细胞白血病患者的年龄也会更高。中华医学杂志，2012,34(4):327-335。(C) 2011 Wiley期刊公司
Human T-cell leukemia virus type-1 (HTLV-1), a major source of adult T-cell leukemia and related diseases, is endemic to southwestern Japan. Mother-to-infant transmission via breast milk is an important route of infection, and establishing programs to prevent such transmission requires exact figures on the HTLV-1 prevalence rate and the number of carriers. Therefore, the seroprevalence of HTLV-1 among 1,196,321 Japanese first-time blood donors from 2006 to 2007 was investigated. A total of 3,787 of such donors were confirmed to be positive for anti-HTLV-1 antibody. By applying a fitness curve to the age ranges outside the blood donor age range, the present number of HTLV-1 carriers covering ages from 0 to 99 years was estimated to be at least 1.08 million in Japan; this value was 10% lower than that reported in 1988. The adjusted overall prevalence rates were estimated to be 0.66% and 1.02% in men and women, respectively. The peak in carrier numbers was found among individuals in their 70s, which is a shift from the previous peak observed in the 1988 database among individuals in their 50s. Carriers were distributed not only in the endemic southwestern region of Japan, but throughout the country, particularly in the greater Tokyo metropolitan area. By applying population projections, it was calculated that the carrier number will decrease by half in the next two decades; however, the carrier population will age over that interval, meaning that the age of patients with adult T-cell leukemia will also be higher. J. Med. Virol. 84:327-335, 2012. (C) 2011 Wiley Periodicals, Inc.