Female schizophrenia patients have prepulse inhibition deficits
Female schizophrenia patients have prepulse inhibition deficits
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DOI：
10.1016/j.biopsych.2004.12.030
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发表时间：
2005-04-01
影响因子：
10.6
通讯作者：
Swerdlow, NR
中科院分区：
文献类型：
--
作者：
Braff, DL;Light, GA;Swerdlow, NR
背景：惊吓的脉冲前抑制（PPI）显示性畸形：女性PPI水平低于男性，且PPI有月经周期变化。许多研究报告了男性精神分裂症患者的PPI缺陷；最近的一份报告发现，男性患者存在PPI缺陷，而女性患者没有。本研究旨在确定女性精神分裂症患者的PPI水平是否低于正常女性。方法：对25例女性精神分裂症患者和26例正常女性患者进行惊吓范式测试，在70 dB背景下使用115 dB惊吓脉冲和8、16 dB预脉冲，预脉冲间隔分别为30和120 msec。结果：与正常女性相比，女性患者PPI明显降低，特别是当使用16 dB预脉冲时。与正常受试者相比，患者也表现出较低习惯水平的不显著趋势。结论：在当前的范式和受试者习得条件下，女性精神分裂症患者PPI水平明显低于正常女性。
Background: Prepulse inhibition (PPI) of startle shows sexual domorphism: women have lower levels of PPI than do men, and have menstrual cycle shifts in PPI. Many studies report PPI deficits in male schizophrenia patients; one recent report identified PPI deficits in male but not female patients. This study was designed to determine whether female schizophrenia patients have lower levels of PPI than, normal females.Methods: Twenty-five female schizophrenia patients, and 26 normal females were tested in a startle paradigm using 115 dB startle pulses and prepulses of 8 and 16 dB above a 70 dB background, with 30 and 120 msec prepulse intervals.Results: Female patients bad significantly less PPI compared with normal females, particularly when 16 dB prepulses were utilized. Patients also exhibited a nonsignificant trend towards lower levels of habituation compared to normal subjects.Conclusions: Under the present paradigmatic and subject acquisition conditions, female schizophrenia patients bad PPI deficits compared to normal females.