Influence of exposure to pesticides on serum components and enzyme activities of cytotoxicity among intensive agriculture farmers
Influence of exposure to pesticides on serum components and enzyme activities of cytotoxicity among intensive agriculture farmers
复制标题
DOI：
10.1016/j.envres.2006.03.002
复制
发表时间：
2006-09-01
影响因子：
8.3
通讯作者：
Pla, Antonio
中科院分区：
文献类型：
--
作者：
Hernandez, Antonio F.;Gomez, M. Amparo;Pla, Antonio
虽然急性农药中毒对目前使用最多的农药的影响是众所周知的，但几乎没有任何关于长期低剂量接触后对健康影响的数据。尚未解决的主要问题包括在没有中毒的情况下适度接触的影响。有机磷以外的杀虫剂使用量的增加使得更难找到关联。在这项研究中，一个队列的106个密集的农业工人进行了两次评估，在喷洒季节的过程中的血清生化变化，即酶反应细胞毒性（AST，ALT，LDH，CK，和氨基氧化酶）和其他生化参数，如肾毒性（尿素，肌酐）和血脂（胆固醇和甘油三酯）的标志物。使用了几个估计农药接触的标准，其中最重要的是血清。从基线到峰值暴露，胆碱酯酶抑制大于25%。我们的研究结果显示，农药暴露与AST（活性增加），LDH和氨基氧化酶（活性降低）的变化以及血清肌酐和磷（分别为较低和较高的水平）的变化。这些结果为肝功能极轻微损害提供了支持，但总体而言，这些结果与无临床显著肝毒性一致。有趣的是，对氧磷酶-1 R等位基因被发现是一个独立的预测率较高的AST和较低的氨基氧化酶的比率，使它可能发挥支持作用，作为一个个体标记的农药引起的健康影响的敏感性。总之，不同的生物标志物可用于检测农药的早期生物化学效应之前，不良的临床健康影响发生。(c)2006年爱思唯尔公司All rights reserved.
Although the effects of acute pesticide poisoning are well known for the pesticides most currently used, hardly any data exist on health effects after long-term low-dose exposures. Major unresolved issues include the effect of moderate exposure in the absence of poisoning. The increased utilization of pesticides other than organophosphates makes it even more difficult to find associations. In this study a cohort of 106 intensive agriculture workers were assessed twice during the course of a spraying season for changes in serum biochemistry, namely enzymes reflecting cytotoxicity (AST, ALT, LDH, CK, and amino-oxidase) and other biochemical parameters, such as markers of nephrotoxicity (urea, creatinine) and lipid profile (cholesterol and triglycerides). Several criteria for estimating pesticide exposure were used, the most important one being serum. cholinesterase depression greater than 25% from baseline to peak exposure. Our results revealed an association of pesticide exposure with changes in AST (increased activity), LDH, and amino-oxidase (decreased activity) as well as with changes in serum creatinine and phosphorus (lower and higher levels, respectively). These results provide support for a very slight impairment of the liver function, but overall these findings are consistent with no clinically significant hepatotoxicity. Intriguingly, paraoxonase-1 R allele was found to be an independent predictor of higher rates of AST and lower rates of amino-oxidase, so that it may play a supporting role as an individual marker of susceptibility on pesticide-induced health effects. In conclusion, different biomarkers might be used to detect early biochemical effects of pesticides before adverse clinical health effects occur. (c) 2006 Elsevier Inc. All rights reserved.