Neural mechanisms supporting maladaptive food choices in anorexia nervosa.
Neural mechanisms supporting maladaptive food choices in anorexia nervosa.
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DOI：
10.1038/nn.4136
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发表时间：
2015-11
影响因子：
25
通讯作者：
Walsh BT
中科院分区：
文献类型：
--
作者：
Foerde K;Steinglass JE;Shohamy D;Walsh BT
人们经常做出错误的选择，尽管知道负面后果。我们发现，患有神经性厌食症的人，在选择食物时会做出适应不良的食物选择，以至于饥饿，在选择吃什么时，背侧纹状体比健康对照组更活跃，并且额纹状体回路的活动与他们第二天的实际食物消耗量相关。
People routinely make poor choices, despite knowledge of negative consequences. We found that individuals with Anorexia Nervosa, who make maladaptive food choices to the point of starvation, engaged the dorsal striatum more than healthy controls when making choices about what to eat, and that activity in fronto-striatal circuits was correlated with their actual food consumption in a meal the next day.