ETHANOL-INDUCED ACTIVATION OF ADENINE-NUCLEOTIDE TURNOVER - EVIDENCE FOR A ROLE OF ACETATE
ETHANOL-INDUCED ACTIVATION OF ADENINE-NUCLEOTIDE TURNOVER - EVIDENCE FOR A ROLE OF ACETATE
复制标题
DOI：
10.1172/jci111512
复制
发表时间：
1984-01-01
影响因子：
15.9
通讯作者：
FOX, IH
中科院分区：
文献类型：
--
作者：
PUIG, JG;FOX, IH
饮酒会减少尿酸盐的排泄并增加尿酸盐的产生，从而导致高尿酸血症。先前的研究表明，乙醇给药通过增加 ATP 降解为尿酸前体来增加尿酸的产生。为了检验乙醇诱导的尿酸生成增加是由于乙酸盐代谢和三磷酸腺苷周转增加所致的假设，静脉注射向 5 名正常受试者给予乙酸钠、氯化钠和乙醇（0.1 mmol/kg 每分钟，持续 1 小时）。血浆醋酸水平从 0.04.+- 增加。 0.1 mM（平均值 .+-. SE）至峰值 0.35 .+-. 0.07 mM 至 0.08 .+-。醋酸盐和乙醇输注期间分别为 0.01 mM。尿氧嘌呤增加至 223 .+-。 13% 和 316 .+-.醋酸盐和乙醇输注期间分别为基线值的 44%。来自用[8-14C]腺嘌呤标记的腺嘌呤核苷酸池的尿液放射性增加至171.+-。 27% 至 128 .+-。醋酸盐和乙醇输注后基线值的 8%。乙醇和乙酸盐均通过增强腺嘌呤核苷酸库的周转来明显增加嘌呤核苷酸的降解。乙酸代谢可能导致与乙醇摄入相关的尿酸盐产生增加。 [讨论了饮酒作为痛风性关节炎的原因。]
Consumption of alcohol causes hyperuricemia by decreasing urate excretion and increasing its production. Previous studies indicate that ethanol administration increases uric acid production by increasing ATP degradation to uric acid precursors. To test the hypothesis that ethanol-induced increased urate production results from acetate metabolism and enhanced adenosine triphosphate turnover, i.v. sodium acetate, sodium chloride and ethanol (0.1 mmol/kg per min for 1 h) were given to 5 normal [human] subjects. Acetate plasma levels increased from 0.04 .+-. 0.1 mM (mean .+-. SE) to peak values of 0.35 .+-. 0.07 mM and to 0.08 .+-. 0.01 mM during acetate and ethanol infusions, respectively. Urinary oxypurines increased to 223 .+-. 13% and 316 .+-. 44% of the baseline values during acetate and ethanol infusions, respectively. Urinary radioactivity from the adenine nucleotide pool labeled with [8-14C]adenine increased to 171 .+-. 27% and to 128 .+-. 8% of the baseline values after acetate and ethanol infusions. Both ethanol and acetate evidently increases purine nucleotide degradation by enhancing the turnover of the adenine nucleotide pool. Acetate metabolism may contribute to the increased production of urate associated with ethanol intake. [Alcohol consumption as a cause of gouty arthritis is discussed.].