Effects of mutant steel alleles on leukemogenesis and life-span in the mouse.
Effects of mutant steel alleles on leukemogenesis and life-span in the mouse.
复制标题
突变钢等位基因对小鼠白血病发生和寿命的影响。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
E. Murphy
中科院分区：
文献类型：
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作者：
E. Murphy
steel基因座的突变等位基因产生先天性贫血、不育和缺乏毛发色素沉着的多效性效应。品系（WC/Re X C57 BL/6）F1 Sl/Sld小鼠的寿命仅为杂合子和纯合子正常对照的一半，仅在steel位点上不同。37%的Sl/Sld基因型小鼠在平均370 +/-25天时自发发生淋巴细胞白血病，5%的杂合子和纯合子正常对照在965 +/-41天时自发发生淋巴细胞白血病。56%的Sl/Sld小鼠在平均441 ± 21天时发生严重的溃疡性皮炎，20%的杂合子和纯合子正常对照在722 ± 50天时发生。突变的钢铁等位基因提供了一个机会，研究慢性贫血的作用，寿命缩短和自发性白血病的基因作用机制。
Mutant alleles at the steel locus produce the pleiotropic effects of congenital anemia, sterility, and lack of hair pigmentation. Strain (WC/Re X C57BL/6)F1 Sl/Sld mice lived only half as long as heterozygotes and homozygous normal controls, differing only at the steel locus. Lymphocytic leukemia developed spontaneously in 37% of mice of the Sl/Sld genotype at an average age of 370 +/- 25 days and in 5% of heterozygotes and homozygous normal controls at 965 +/- 41 days. Severe ulcerative dermatitis occurred in 56% of Sl/Sld mice at an average age o4f 441 +/- 21 days and in 20% of heterozygotes and homozygous normal controls at 722 +/- 50 days. The mutant steel alleles provided an opportunity for study of the role of chronic anemia in life shortening and of a mechanism of gene action in spontaneous leukemogenesis.