Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database.
Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database.
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DOI：
10.1051/parasite/2020062
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Rinaldi L
中科院分区：
文献类型：
--
作者：
Rose Vineer H;Morgan ER;Hertzberg H;Bartley DJ;Bosco A;Charlier J;Chartier C;Claerebout E;de Waal T;Hendrickx G;Hinney B;Höglund J;Ježek J;Kašný M;Keane OM;Martínez-Valladares M;Mateus TL;McIntyre J;Mickiewicz M;Munoz AM;Phythian CJ;Ploeger HW;Rataj AV;Skuce PJ;Simin S;Sotiraki S;Spinu M;Stuen S;Thamsborg SM;Vadlejch J;Varady M;von Samson-Himmelstjerna G;Rinaldi L
蠕虫感染在放牧反刍动物生产系统中普遍存在，并造成重大成本和生产损失。寄生虫的抗虫性现在在整个欧洲广泛存在，尽管我们在一些区域和国家的知识仍存在差距。反刍兽药对现代反刍牲畜生产的可持续性构成重大威胁，导致生产力下降，动物健康和福利受到损害，并因寄生和农场投入增加而增加温室气体排放。需要更好地了解欧洲反刍兽药的严重程度，以制定和倡导更可持续的寄生虫控制方法。欧洲成本行动“COMBAR”（对抗反刍动物的虫虫耐药性）的成员整理了欧洲已发表和未发表的胃肠线虫（GIN）和肝吸虫（肝片形吸虫）的AR研究数据库，并结合了先前对GIN中AR的系统评价数据。共有197份关于GIN中的AR的出版物可供分析，其中包括1980-2020年期间22个国家的535项研究。整个欧洲大陆都有关于急性呼吸道感染的报告，有些报告指出国内发病率很高。在整个研究期间，欧洲AR患病率的启发式样本量加权估计，按驱虫类分层，在0和48%之间变化。估计的区域（国家）流行率具有高度异质性，根据畜牧业和驱虫类的不同，范围在0%至100%之间，并且通常随着一个国家研究工作的增加而增加。在少数具有充分纵向数据的国家中，随着时间的推移，GIN所有驱虫类的AR都有增加的趋势：自2010年以来绵羊和山羊的汇总结果显示，苯并咪唑（BZ）的平均耐药率为86%，大环内酯（莫西丁除外）（ML）为52%，左旋咪唑（LEV）为48%，莫西丁（MOX）为21%。在各种研究中，所有主要的GIN属都存活了下来。在牛中，AR的患病率在不同的虫类中从0-100% （BZ和ML）、0-17% （LEV）和0-73% （MOX）不等，库伯氏和奥斯特塔吉氏处理后均存活。6个国家的21项研究报告了肝梭菌的疑似AR。对于GIN，特别是F.肝炎，有一种偏向于对疑似AR的个体农场进行优先抽样的倾向，研究工作偏向于西欧，特别是英国。在实时数据库中持续获取未来结果，努力避免农场招聘中的偏见，对AR进行更准确的测试，以及农业行业和政策制定者对AR重要性的更强认识，将支持对AR的影响因素进行更复杂的分析，并制定有效战略以减缓其传播。
Helminth infections are ubiquitous in grazing ruminant production systems, and are responsible for significant costs and production losses. Anthelmintic Resistance (AR) in parasites is now widespread throughout Europe, although there are still gaps in our knowledge in some regions and countries. AR is a major threat to the sustainability of modern ruminant livestock production, resulting in reduced productivity, compromised animal health and welfare, and increased greenhouse gas emissions through increased parasitism and farm inputs. A better understanding of the extent of AR in Europe is needed to develop and advocate more sustainable parasite control approaches. A database of European published and unpublished AR research on gastrointestinal nematodes (GIN) and liver fluke (Fasciola hepatica) was collated by members of the European COST Action “COMBAR” (Combatting Anthelmintic Resistance in Ruminants), and combined with data from a previous systematic review of AR in GIN. A total of 197 publications on AR in GIN were available for analysis, representing 535 studies in 22 countries and spanning the period 1980–2020. Reports of AR were present throughout the European continent and some reports indicated high within-country prevalence. Heuristic sample size-weighted estimates of European AR prevalence over the whole study period, stratified by anthelmintic class, varied between 0 and 48%. Estimated regional (country) prevalence was highly heterogeneous, ranging between 0% and 100% depending on livestock sector and anthelmintic class, and generally increased with increasing research effort in a country. In the few countries with adequate longitudinal data, there was a tendency towards increasing AR over time for all anthelmintic classes in GIN: aggregated results in sheep and goats since 2010 reveal an average prevalence of resistance to benzimidazoles (BZ) of 86%, macrocyclic lactones except moxidectin (ML) 52%, levamisole (LEV) 48%, and moxidectin (MOX) 21%. All major GIN genera survived treatment in various studies. In cattle, prevalence of AR varied between anthelmintic classes from 0–100% (BZ and ML), 0–17% (LEV) and 0–73% (MOX), and both Cooperia and Ostertagia survived treatment. Suspected AR in F. hepatica was reported in 21 studies spanning 6 countries. For GIN and particularly F. hepatica, there was a bias towards preferential sampling of individual farms with suspected AR, and research effort was biased towards Western Europe and particularly the United Kingdom. Ongoing capture of future results in the live database, efforts to avoid bias in farm recruitment, more accurate tests for AR, and stronger appreciation of the importance of AR among the agricultural industry and policy makers, will support more sophisticated analyses of factors contributing to AR and effective strategies to slow its spread.
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Fasciola Hepatica表现出高水平的遗传多样性，缺乏种群结构和高基因流量：对耐药性的可能影响。
影响因子：
4
作者：
Beesley NJ;Williams DJ;Paterson S;Hodgkinson J
通讯作者：
Hodgkinson J
影响因子：
2.6
作者：
Grimshaw, WTR;Hong, C;Hunt, KR
通讯作者：
Hunt, KR
影响因子：
2.6
作者：
Jack, Corin;Hotchkiss, Emily;Bartley, David. J.
通讯作者：
Bartley, David. J.
影响因子：
2.3
作者：
Catelan, Dolores;Rinaldi, Laura;Biggeri, Annibale
通讯作者：
Biggeri, Annibale
影响因子：
3.6
作者：
Kenyon, Fiona;Dick, Jan M.;Skuce, Philip J.
通讯作者：
Skuce, Philip J.