Medication patterns in patients with autism: Temporal, regional, and demographic influences
Medication patterns in patients with autism: Temporal, regional, and demographic influences
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DOI：
10.1089/cap.2005.15.116
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发表时间：
2005-02-01
影响因子：
1.9
通讯作者：
Van Bourgondien, ME
中科院分区：
文献类型：
--
作者：
Aman, MG;Lam, KSL;Van Bourgondien, ME
到目前为止，关于自闭症患者使用精神药物的调查相对较少。数据分析来自采用相同问卷和调查方法的三项全州调查。第一项研究是在1992-1993年间在北卡罗来纳州自闭症协会进行的(NC-1，n=838；Aman等人)。1995年)；第二项研究是1999年在俄亥俄州自闭症协会进行的(俄亥俄州，n=417；Aman等人)。2003年)，2001年在北卡罗来纳州的自闭症协会再次进行了第三次研究(NC-2，n=1538；朗沃西-林等人)。2002年)。有效率为48%~56%。通过比较NC-1和NC-2的数据来检查纵向趋势，通过比较NC-2和俄亥俄州的数据来评估区域影响。从1993年到2001年，抗抑郁药的使用有了很大的增长，抗精神病药物、精神刺激剂、α-激动剂和β-受体阻滞剂的使用也出现了显著的增长。在患有自闭症的青少年中，使用任何精神药物的比例从NC-1的30.5%上升到NC-2的45.2%。精神药物的用药模式在北卡罗来纳州和俄亥俄州都非常一致，除了俄亥俄州使用了明显更多的自闭症补充剂。我们还检查了研究对象和人口统计学变量，发现了几个与精神药物使用密切相关的因素。更大的年龄和残疾，以及更多的限制安置，与使用几类药物有关。对这些模式的了解可能有助于家庭和医疗规划者预测未来的需求。
To date, there have been relatively few surveys of psychotropic medicine use in individuals with autism. Data were analyzed from three statewide surveys that employed the same questionnaire and survey methodology. The first was done in the Autism Society of North Carolina in 1992-1993 (NC-1, n = 838; Aman et al. 1995); the second was done in the Autism Society of Ohio in 1999 (Ohio, n = 417; Aman et al. 2003), and the third was done again in the Autism Society of North Carolina in 2001 (NC-2, n = 1538; Langworthy-Lam et al. 2002). Response rates ranged from 48%-56%. Longitudinal trends were examined by comparing the NC-1 and NC-2 data, and regional effects were assessed by comparing the NC-2 and Ohio data. There was a very large increase in antidepressant utilization from 1993 to 2001, with significant increases also occurring for antipsychotics, psychostimulants, and alpha-agonists and beta-blockers. Among youths with autism, the use of any psychotropic increased from 30.5% in NC-1 to 45.2% in NC-2. Psychotropic medication patterns were remarkably consistent across North Carolina and Ohio, except that significantly more autism supplements were used in Ohio. We also examined subject and demographic variables across studies and found several robust correlates of psychotropic medication use. Greater age and handicap, and more restrictive placements, were associated with the use of several drug classes. Knowledge of these patterns may help families and medical planners anticipate future needs.