Inhibition of Cell Proliferation by D-Ribose and Deoxy-D-ribose
Inhibition of Cell Proliferation by D-Ribose and Deoxy-D-ribose
复制标题
D-核糖和脱氧-D-核糖对细胞增殖的抑制
DOI：
10.3181/00379727-180-42172
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发表时间：
1985
影响因子：
--
通讯作者：
C. Franceschi
中科院分区：
文献类型：
--
作者：
M. Marini;G. Zunica;C. Franceschi
摘要D-核糖和脱氧D-核糖在其他单糖几乎没有影响或没有影响的浓度下抑制各种细胞（分裂和非分裂，正常和肿瘤，自由漂浮和底物粘附，人类和小鼠）的DNA，RNA和蛋白质合成。抑制是不可逆的，并与糖浓度和接触时间成正比。然而，仅在孵育24小时后观察到第一个效应，并缓慢进展至细胞死亡。这两种糖是否具有相同的作用机制尚不清楚。无论如何，它们都会严重扰乱分裂和非分裂细胞的代谢过程。
Abstract D-Ribose and deoxy-D-ribose inhibited DNA, RNA, and protein synthesis in a wide variety of cells (dividing and nondividing, normal and neoplastic, freely floating and substrate adhering, human and murine) at concentrations at which other monosaccharides have little or no effect. Inhibition was irreversible and proportional to the sugar concentration and time of contact. However, the first effects were seen only after 24 hr of incubation and progressed slowly to cell death. Whether the two sugars share the same mechanisms of action is not known. In any case, they deeply derange metabolic processes in both dividing and nondividing cells.
单糖抑制自发但非抗体依赖性细胞介导的细胞毒性：内源凝集素可能介导自发细胞介导的细胞毒性的证据。
影响因子：
6.4
作者：
MacDermott,RP;Kienker,LJ;Bertovich,MJ;Muchmore,AV
通讯作者：
Muchmore,AV