New genetic associations detected in a host response study to hepatitis B vaccine
New genetic associations detected in a host response study to hepatitis B vaccine
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DOI：
10.1038/gene.2010.1
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发表时间：
2010-04-01
影响因子：
5
通讯作者：
Seielstad, M.
中科院分区：
文献类型：
--
作者：
Davila, S.;Froeling, F. E. M.;Seielstad, M.
对B型肝炎疫苗接种的免疫反应在个体之间差异很大，5 - 10%的健康人不能产生保护水平的抗体。有几个因素与决定这种反应有关，主要是个体遗传变异和年龄。为了确定参与B型肝炎疫苗接种反应的基因，在印度尼西亚队列中对914个免疫基因中的6091个单核苷酸多态性（SNP）进行了两阶段调查，其中981个个体显示抗-HBs水平正常，而665个个体在初始剂量疫苗接种后18个月显示抗-HBs水平不可检测。在第一阶段确定的275个SNP中（476个正常/372个无应答者），P
The immune response to hepatitis B vaccination differs greatly among individuals, with 5-10% of healthy people failing to produce protective levels of antibodies. Several factors have been implicated in determining this response, chiefly individual genetic variation and age. Aiming to identify genes involved in the response to hepatitis B vaccination, a two-stage investigation of 6091 single-nucleotide polymorphisms (SNPs) in 914 immune genes was performed in an Indonesian cohort of 981 individuals showing normal levels of anti-HBs versus 665 individuals displaying undetectable levels of anti-HBs 18 months after initial dose of the vaccine. Of 275 SNPs identified in the first stage (476 normal/372 nonresponders) with P